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Table 1 Patients’ baseline characteristics according to statin usage

From: Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: a prospective observational cohort study

 

All

ARDS

P value

(n = 404)

without statins

with statins

(n = 296)

(n = 108)

Age, years

63 ± 15

60 ± 16

70 ± 11

<0.0001

Male, %

68

65

76

0.0533

Body mass index

28 ± 7

28 ± 8

28 ± 5

0.4304

Severity of sepsis

    

 Sepsis/severe sepsis, %

36

32

48

0.0035

 Septic shock, %

64

68

52

0.0035

Sequential Organ Failure Assessment score

9.6 ± 3.7

9.9 ± 3.8

8.9 ± 3.4

0.0158

Acute Physiology and Chronic Health Evaluation (APACHE II) score

22.1 ± 6.8

22.1 ± 7.0

22.1 ± 6.0

0.9888

Comorbidities, %

    

 Hypertension

56

48

78

<0.0001

 History of myocardial infarction

6

2

19

<0.0001

 Chronic obstructive pulmonary disease

18

18

20

0.5615

 Renal dysfunction

11

9

18

0.0192

 Noninsulin-dependent diabetes mellitus

9

7

15

0.0332

 Insulin-dependent diabetes mellitus

11

9

19

0.0069

 Chronic liver disease

7

7

7

1.0000

 History of cancer

20

21

19

0.8891

 History of stroke

5

4

11

0.0073

Recent surgical history, %

    

 Elective surgery

26

21

39

0.0005

 Emergency surgery

54

56

49

0.2168

 No history of surgery

20

23

12

0.0169

Site of infection, %

   

0.1339

 Lung

60

57

70

 

 Abdomen

23

25

17

 

 Bone or soft tissue

5

5

2

 

 Surgical wound

2

2

1

 

 Urogenital

2

2

2

 

 Primary bacteremia

6

5

7

 

 Other

4

4

1

 

Organ support, %

    

 Mechanical ventilation

90

91

86

0.1393

 Use of vasopressor

64

68

52

0.0035

 Renal replacement therapy

10

9

11

0.5697

Statin drugs, %

    

 Simvastatin

23

 

87

 

 Pravastatin

2

 

6

 

 Atorvastatin

1

 

6

 

 Fluvastatin

0

 

1

 
  1. The data are presented as the mean ± SD or as a percentage