| All | Severe ARDS | P value | |
---|---|---|---|---|
(n = 114) | without statins | with statins | ||
(n = 88) | (n = 26) | |||
Sequential Organ Failure Assessment (SOFA) | 9.0 ± 3.7 | 9.3 ± 3.9 | 7.7 ± 2.6 | 0.1051 |
SOFA-Respiratory score | 2.6 ± 0.6 | 2.6 ± 0.6 | 2.6 ± 0.6 | 0.9677 |
SOFA-Cardiovascular score | 2.0 ± 1.1 | 2.1 ± 1.1 | 1.5 ± 1.0 | 0.0063 |
SOFA-Central nervous System score | 2.4 ± 1.0 | 2.5 ± 1.0 | 2.0 ± 1.0 | 0.0203 |
SOFA-Renal score | 1.0 ± 1.2 | 0.9 ± 1.2 | 1.1 ± 1.0 | 0.2110 |
SOFA-Coagulation score | 0.5 ± 0.7 | 0.6 ± 0.8 | 0.3 ± 0.4 | 0.2734 |
SOFA-Hepatic score | 0.5 ± 0.7 | 0.5 ± 0.8 | 0.3 ± 0.5 | 0.0218 |
Mortality analysis, % | Â | Â | Â | Â |
 Death at day 28 | 32 | 38 | 12 | 0.0153 |
 Death at day 90 | 42 | 47 | 27 | 0.1126 |
Length of stay in ICU, days | 20 ± 15 | 19 ± 15 | 22 ± 16 | 0.4290 |
Organ support-free days | Â | Â | Â | Â |
 Vasopressor-free days | 10 ± 7 | 9 ± 7 | 13 ± 7 | 0.0034 |
 Ventilator-free days | 3 ± 3 | 2 ± 3 | 3 ± 3 | 0.1824 |
 Dialysis-free days | 15 ± 8 | 14 ± 8 | 17 ± 8 | 0.2532 |
 Extracorporeal membrane oxygenation-free days | 15 ± 9 | 15 ± 9 | 18 ± 9 | 0.0873 |
Inflammatory values | Â | Â | Â | Â |
 Leucocytes (1000/μL) | 13 ± 5 | 13 ± 5 | 12 ± 4 | 0.5168 |
 C-reactive protein (mg/L) (n) | 155 ± 84 (46) | 166 ± 85 (33) | 125 ± 79 (13) | 0.1400 |
 Procalcitonin (ng/dL) (n) | 6.4 ± 14.0 (109) | 7.3 ± 15.1 (85) | 3.2 ± 9.5 (24) | 0.0743 |
Kidney values | Â | Â | Â | Â |
 Urine output (mL/day) | 2977 ± 1442 | 2911 ± 1440 | 3201 ± 1457 | 0.5659 |
 Urine output (mL/kg/h) | 1.5 ± 0.8 | 1.4 ± 0.7 | 1.5 ± 0.8 | 0.7356 |
 Creatinine (mg/dL) | 1.4 ± 0.9 | 1.3 ± 1.0 | 1.6 ± 0.8 | 0.0363 |
Liver values | Â | Â | Â | Â |
 AST (IU/L) (n) | 391 ± 1248 (81) | 472 ± 1395 (64) | 85 ± 80 (17) | 0.0611 |
 ALT (IU/L) (n) | 135 ± 288 (113) | 157 ± 324 (87) | 63 ± 57 (26) | 0.1257 |
 Bilirubin (mg/dL) | 1.5 ± 2.7 | 1.7 ± 3.0 | 0.8 ± 0.7 | 0.0511 |