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Table 4 Disease severity among patients with severe acute respiratory distress syndrome (ARDS) according to statin therapy

From: Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: a prospective observational cohort study

 

All

Severe ARDS

P value

(n = 114)

without statins

with statins

(n = 88)

(n = 26)

Sequential Organ Failure Assessment (SOFA)

9.0 ± 3.7

9.3 ± 3.9

7.7 ± 2.6

0.1051

SOFA-Respiratory score

2.6 ± 0.6

2.6 ± 0.6

2.6 ± 0.6

0.9677

SOFA-Cardiovascular score

2.0 ± 1.1

2.1 ± 1.1

1.5 ± 1.0

0.0063

SOFA-Central nervous System score

2.4 ± 1.0

2.5 ± 1.0

2.0 ± 1.0

0.0203

SOFA-Renal score

1.0 ± 1.2

0.9 ± 1.2

1.1 ± 1.0

0.2110

SOFA-Coagulation score

0.5 ± 0.7

0.6 ± 0.8

0.3 ± 0.4

0.2734

SOFA-Hepatic score

0.5 ± 0.7

0.5 ± 0.8

0.3 ± 0.5

0.0218

Mortality analysis, %

    

 Death at day 28

32

38

12

0.0153

 Death at day 90

42

47

27

0.1126

Length of stay in ICU, days

20 ± 15

19 ± 15

22 ± 16

0.4290

Organ support-free days

    

 Vasopressor-free days

10 ± 7

9 ± 7

13 ± 7

0.0034

 Ventilator-free days

3 ± 3

2 ± 3

3 ± 3

0.1824

 Dialysis-free days

15 ± 8

14 ± 8

17 ± 8

0.2532

 Extracorporeal membrane oxygenation-free days

15 ± 9

15 ± 9

18 ± 9

0.0873

Inflammatory values

    

 Leucocytes (1000/μL)

13 ± 5

13 ± 5

12 ± 4

0.5168

 C-reactive protein (mg/L) (n)

155 ± 84 (46)

166 ± 85 (33)

125 ± 79 (13)

0.1400

 Procalcitonin (ng/dL) (n)

6.4 ± 14.0 (109)

7.3 ± 15.1 (85)

3.2 ± 9.5 (24)

0.0743

Kidney values

    

 Urine output (mL/day)

2977 ± 1442

2911 ± 1440

3201 ± 1457

0.5659

 Urine output (mL/kg/h)

1.5 ± 0.8

1.4 ± 0.7

1.5 ± 0.8

0.7356

 Creatinine (mg/dL)

1.4 ± 0.9

1.3 ± 1.0

1.6 ± 0.8

0.0363

Liver values

    

 AST (IU/L) (n)

391 ± 1248 (81)

472 ± 1395 (64)

85 ± 80 (17)

0.0611

 ALT (IU/L) (n)

135 ± 288 (113)

157 ± 324 (87)

63 ± 57 (26)

0.1257

 Bilirubin (mg/dL)

1.5 ± 2.7

1.7 ± 3.0

0.8 ± 0.7

0.0511

  1. The data are presented as the mean ± SD or as a percentage