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Table 1 Baseline characteristics of the original and the extended cohort of the Rotterdam Study

From: The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam Study

  RS-I RS-II P value for difference
  N = 7,003 N = 2,953
Age, years 69.4 (9.1) 65.0 (8.3) <0.001
Sex, female 4187 (59.8 %) 1661 (56.2 %) 0.15
Body mass index    
 <18.5 69 (1.0 %) 15 (0.6 %) 0.65
 18.5–25 2486 (37.5 %) 790 (29.9 %) Reference
 25–30 3097 (46.7 %) 1286 (48.6 %) <0.001
 >30 977 (14.7 %) 555 (21.0 %) <0.001
Hypertension 3793 (56.3 %) 1688 (61.9 %) <0.001
Diabetes mellitus 727 (10.5 %) 319 (10.9 %) 0.001
Total cholesterol, mmol/L 6.6 (1.2) 5.8 (1.0) <0.001
HDL cholesterol, mmol/L 1.3 (0.4) 1.4 (0.4) 0.004
Lipid lowering medication 164 (2.3 %) 367 (12.5 %) <0.001
Smoking    
 Former 2848 (41.7 %) 1381 (47.4 %) 0.001
 Current 1560 (22.8 %) 678 (23.3 %) 0.60
Educational level    
 Intermediate 2540 (37.3 %) 1429 (49.4 %) <0.001
 Low 3700 (54.3 %) 975 (33.7 %) <0.001
Stroke 175 (2.5 %) 94 (3.2 %) <0.001
Coronary heart disease 535 (8.4 %) 163 (6.1 %) 0.04
Heart failure 220 (3.3 %) 31 (1.2 %) 0.01
Atrial fibrillation 316 (4.9 %) 79 (3.6 %) 0.44
  1. Data are presented as means (standard deviations) or numbers (percentages). Percentages are calculated without missing data. Abbreviations: RS-I, Rotterdam Study I, original cohort; RS-II, Rotterdam Study II, extended cohort; N , number of participants; HDL, High density lipoprotein. Differences between the original and extended cohort were calculated using logistic regression models, adjusting for age and sex where appropriate