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Table 3 Population attributable risk (PAR) of cardiovascular diseases in the original and extended cohort

From: The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam Study

  RS-I RS-II
  n/N 624/7,003 n/N 145/2,953
  HR (95 % CI) Combined PAR per risk factor (95 % CI) HR (95 % CI) Combined PAR per risk factor (95 % CI)
Total without CVD   0.23 (0.05–0.62)   0.30 (0.06–0.76)
Stroke 1.43 (1.00–2.04) 0.02 (0.00–0.05) 1.70 (0.86–3.37) 0.03 (0.01–0.13)
Coronary heart disease 1.00 (0.73–1.38) 0.00 (0.00–1.00) 1.38 (0.79–2.43) 0.03 (0.00–0.20)
Heart failure 0.87 (0.59–1.28) NA 0.33 (0.04–2.39) NA
Atrial fibrillation 1.32 (0.99–1.77) 0.02 (0.01–0.06) 0.36 (0.13–0.97) NA
Total including CVD   0.25 (0.07–0.62)   0.33 (0.07–0.77)
  1. Estimates represent hazard ratios (95 % CIs) and population attributable risks (PARs; 95 % CIs). Models were adjusted for age and sex, and for body mass index, hypertension, diabetes mellitus, total cholesterol/HDL cholesterol ratio, lipid-lowering medication, smoking, educational level, stroke, coronary heart disease, heart failure, and atrial fibrillation, if appropriate. For some risk factors, PARs could not be calculated as these risk factors were not related to dementia in the expected direction; these PARs are therefore not applicable (indicated with NA) [25]
  2. Abbreviations: RS-I Rotterdam Study I, original cohort, RS-II Rotterdam Study II, extended cohort, n Number of cases, N Number of people at risk, HR Hazard ratio, CI Confidence interval, PAR Population attributable risk; CVD, Cardiovascular disease; NA, Not applicable