| Model 1 (age, sex and education) | Model 2 (model 1 + health conditions)a | Model 3 (model 2 + disability)b |
---|---|---|---|
Physical frailty phenotype | Â | Â | Â |
Dependence (IRR)c | Fd = 1.77 (1.53–2.04) | F = 1.43 (1.24–1.64) | F = 1.28 (1.10–1.48) |
Heterogeneity | Cochrane’s Q 14.1, 8 df, P = 0.08 | Cochrane’s Q 13.9, 8 df, P = 0.09 | Cochrane’s Q 10.0, 8 df, P = 0.27 |
Higgins I2 = 43 (0–74) | Higgins I2 = 42 (0–73) | Higgins I2 = 20 (0–61) | |
Mortality (HR)e | F = 1.89 (1.72–2.08) | F = 1.51 (1.36–1.68) | F = 1.18 (1.06–1.33) |
Rf = 1.97 (1.68–2.31) | |||
Heterogeneity | Cochrane’s Q 20.1, 9 df, P = 0.02 | Cochrane’s Q 15.0, 9 df, P = 0.09 | Cochrane’s Q 10.8, 9 df, P = 0.29 |
Higgins I2 = 55 (9–78) | Higgins I2 = 40 (0–71) | Higgins I2 = 16 (0–58) | |
Multidimensional phenotype | Â | Â | Â |
Dependence (IRR) | F = 2.15 (1.88–2.46) | F = 1.46 (1.27–1.68) | F = 1.36 (1.18–1.57) |
Heterogeneity | Cochrane’s Q 2.9, 8 df, P = 0.95 | Cochrane’s Q 6.1, 8 df, P = 0.64 | Cochrane’s Q 3.5, 8 df, P = 0.90 |
Higgins I2 = 0 (0–65) | Higgins I2 = 0 (0–65) | Higgins I2 = 0 (0–65) | |
Mortality (HR) | F = 1.96 (1.78–2.15) | F = 1.54 (1.39–1.71) | F = 1.38 (1.24–1.54) |
R = 1.94 (1.66–2.28) | R = 1.53 (1.29–1.81) | R = 1.36 (1.14–1.62) | |
Heterogeneity | Cochrane’s Q 21.1, 9 df, P = 0.01 | Cochrane’s Q 19.7, 9 df, P = 0.02 | Cochrane’s Q 19.8, 9 df, P = 0.02 |
Higgins I2 = 57 (14–79) | Higgins I2 = 54 (7–78) | Higgins I2 = 55 (8–78) |