Table 1 Study characteristics
Characteristic | Number of studiesa (n = 115) | Percentage of studies (%) |
|---|---|---|
Year of publication | Â | |
1990–1994 | 7 | 6.1 |
1995–1999 | 37 | 32.2 |
2000–2004 | 19 | 16.5 |
2005–2009 | 36 | 31.3 |
2010–2013 | 16 | 13.9 |
Geographic region | Â | |
Europe | 42 | 36.5 |
North America | 30 | 26.1 |
Asia | 28 | 24.3 |
Multi-continent | 8 | 7.0 |
Australasia | 3 | 2.6 |
Africa | 2 | 1.7 |
Not reported | 1 | 0.9 |
South America | 1 | 0.9 |
Study design | Â | |
Randomized clinical trial | 112 | 97.4 |
Non-randomized clinical trial | 2 | 1.7 |
Controlled before–after study | 1 | 0.9 |
Study conduct period | Â | Â |
1990–1999 | 1 | 0.9 |
2000–2009 | 15 | 13.0 |
2010–2013 | 1 | 0.9 |
Not reported | 98 | 85.2 |
Duration of follow-up b | Â | |
0 to ≤6 | 9 | 7.8 |
>6 to ≤12 | 2 | 1.7 |
>12 to ≤24 | 79 | 68.7 |
>24 to ≤48 | 17 | 14.8 |
>48 to ≤72 | 2 | 1.7 |
>72 to ≤1 week | 3 | 2.6 |
Not reported | 3 | 2.6 |
Interventions examined: frequency c | Â | Â |
Serotonin antagonists: Reported as administered alone (administered with dexamethasone) | ||
Ondansetron | 79 (7) | 68.70 (6.1) |
Granisetron | 14 (4) | 12.2 (3.5) |
Tropisetron | 15 (0) | 13.0 (0.0) |
Dolasetron | 15 (1) | 13.0 (0.9) |
Palonosetron | 4 (0) | 3.5 (0.0) |
Ramosetron | 3 (1) | 2.6 (0.9) |
Comparator antiemetics: | ||
Butyrophenone | 26 | 22.61 |
Benzamide | 14 | 12.17 |
Dexamethasone | 6 | 5.2 |
Phenothiazine | 2 | 1.7 |
Antihistamine | 3 | 2.61 |
NK-1 | 4 | 3.5 |
Anticholinergic | 0 | 0 |
Serotonin antagonists given with other antiemetic: | ||
Serotonin antagonist + dexamethasone | 13 | 11.3 |
Serotonin antagonist + butyrophenone | 5 | 4.4 |
Serotonin antagonist + benzamide | 0 | 0 |
Serotonin antagonist + antihistamine | 1 | 0.9 |
Serotonin antagonist + NK-1 | 1 | 0.9 |
Serotonin antagonist + phenothiazine | 0 | 0 |
Placebo or no treatment | 86 | 74.78 |
Outcomes examined: frequency d | Â | Â |
Arrhythmia | 53 | 46.1 |
Delirium | 34 | 29.6 |
Mortality | 28 | 24.3 |
QT prolongation | 18 | 15.7 |
Setting | Â | |
Not reported | 71 | 61.7 |
Hospital | 25 | 21.7 |
Medical center | 16 | 13.9 |
Multi-center | 3 | 2.6 |