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Table 6 Comparison of rates of tuberculosis in 216,545 patients with type 2 diabetes (T2DM) categorised by health care utilisation with a matched unexposed cohort

From: Risk of tuberculosis in patients with diabetes: population based cohort study using the UK Clinical Practice Research Datalink

   

Age adjusted

 

Fully adjusted modela

 

Exposure group

Number of patients

TB cases/PYb

Ratec (95 % CI)

Rate ratio

Rate ratio

P-value*

(% of T2DM)

(95 % CI)

(95 % CI)

Patients without diabetes

1,186,844

764/55.87

13.67 (12.74–14.68)

1.00

1.00

 

Patients with T2DM

      

Cholesterol testing rate:

      

Less than once per year

89,989 (41.6)

116/4.42

26.23 (21.87–31.46)

1.91 (1.58–2.33)

1.78 (1.29–2.44)

<0.001

Once per year

88,961 (41.1)

44/5.52

7.97 (5.93–10.71)

0.58 (0.43–0.79)

0.76 (0.50–1.14)

 

Twice or more per year

37,595 (17.3)

29/1.44

20.16 (14.01–29.01)

1.47 (1.02–2.14)

1.98 (1.20–3.27)

 

Blood pressure testing rate:

      

Up to once per year

41,839 (19.3)

55/1.94

28.30 (21.73–36.86)

2.34 (1.78–3.07)

2.49 (1.59–3.92)

<0.001

Once to twice per year

55,983 (25.9)

27/3.36

8.03 (5.51–11.72)

0.60 (0.41–0.88)

0.67 (0.38–1.18)

 

More than twice per year

118,723 (54.8)

108/6.42

16.81 (13.92–20.30)

1.23 (1.00–1.50)

1.34 (0.99–1.81)

 

Influenza vaccination rate:

      

Less than once per year

57,257 (26.4)

84/2.35

35.62 (28.76–44.11)

2.61 (2.08–3.26)

2.91 (2.00–4.23)

<0.001

Once per year

159,288 (73.6)

105/9.02

11.64 (9.61–14.09)

0.85 (0.69–1.04)

0.98 (0.73–1.32)

 
  1. *P-value from likelihood ratio test
  2. aModel adjusted for: age, BMI, smoking status, alcohol status, ethnicity and IMD
  3. bPY: 100,000 person years at risk
  4. cRate: per 100,000 person years
  5. BMI body mass index, CI confidence interval, IMD index of multiple deprivation, TB tuberculosis