Fluorescent nanodiamonds as a relevant tag for the assessment of alum adjuvant particle biodisposition

Table 2 Semi-quantitative study of the progressive decrease of granuloma size in injected muscle with AluDia complex. AluDia Alhydrogel^® and mfND complex, TA tibialis anterior

Days	No granuloma (0)	Small granuloma (+)	Medium granuloma (++)	Large granuloma (+++)	Total
D45	2 %	13 %	24 %	61 %	100 %
D135	2 %	14 %	31 %	54 %	100 %
D180	36 %	22 %	9 %	19 %	100 %
D270	71 %	19 %	10 %	0 %	100 %

Whole TA muscle from three injected animals per time point (n = 3 per time point) were serially cryo-sectionned (a mean number of 90 longitudinal muscle sections were obtained per animal). Each section was categorized into four groups: no granuloma (0), small (+), medium (++) and large (+++) granuloma. Then, percentage of muscle section typing was calculated at each time point

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