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Table 2 Semi-quantitative study of the progressive decrease of granuloma size in injected muscle with AluDia complex. AluDia Alhydrogel® and mfND complex, TA tibialis anterior

From: Fluorescent nanodiamonds as a relevant tag for the assessment of alum adjuvant particle biodisposition

Days No granuloma (0) Small granuloma (+) Medium granuloma (++) Large granuloma (+++) Total
D45 2 % 13 % 24 % 61 % 100 %
D135 2 % 14 % 31 % 54 % 100 %
D180 36 % 22 % 9 % 19 % 100 %
D270 71 % 19 % 10 % 0 % 100 %
  1. Whole TA muscle from three injected animals per time point (n = 3 per time point) were serially cryo-sectionned (a mean number of 90 longitudinal muscle sections were obtained per animal). Each section was categorized into four groups: no granuloma (0), small (+), medium (++) and large (+++) granuloma. Then, percentage of muscle section typing was calculated at each time point