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Table 4 Total hip replacement: differences in costs and outcomes between APEX randomised groups

From: Local anaesthetic wound infiltration in addition to standard anaesthetic regimen in total hip and knee replacement: long-term cost-effectiveness analyses alongside the APEX randomised controlled trials

 

Difference (intervention – control)

 

N

Mean

(95 % CI)

OUTCOMES

   

QALYs

   

QALY gain – available cases a

216

0.064

(0.018 to 0.110)

QALY gain – imputed data b

322

0.052

(0.011 to 0.094)

Primary clinical outcome

   

WOMAC pain score improvement – available cases c

281

4.74

(0.95 to 8.54)

WOMAC pain score improvement – imputed data d

322

5.35

(1.33 to 9.34)

COST

   

Initial inpatient stay

   

Total of inpatient stay – available cases a

273

-£123

(£–364 to £118)

Total of inpatient stay – imputed data b

322

-£32

(£–349 to £285)

Secondary care after initial discharge

   

Inpatient admissions – available cases a

236

£251

(£–114 to £617)

Inpatient admissions – imputed data b

322

£139

(£–174 to £452)

Outpatient visits – available cases a

287

-£2

(£–36 to £32)

Outpatient visits with – imputed data b

322

£4

(£–33 to £42)

Total secondary care cost – available cases a

231

£251

(£–136 to £639)

Total secondary care cost – imputed data b

322

£143

(£–184 to £471)

Community-based resources

   

Total community-based costs – available cases a

202

-£4

(£–51 to £43)

Total community-based costs – imputed data b

322

-£34

(£–83 to £16)

Total NHS cost – complete NHS cost cases a

179

£15

(£–373 to £404)

Total NHS cost – imputed data b

322

£78

(£–404 to £560)

Personal social services (PSS)

   

Total personal social services – available cases a

263

-£83

(£–289 to £123)

Total personal social services – imputed data b

322

-£164

(£–418 to £91)

Total NHS + PSS cost – complete NHS+PSS cost cases a

173

-£94

(£–634 to £446)

Total NHS + PSS cost – imputed data b

322

-£86

(£–634 to £462)

  1. a Adjusted for minimisation variables (baseline WOMAC pain score and surgical approach) and baseline utility for QALYs, robust standard errors
  2. b Adjusted for minimisation variables (and baseline utility for QALYs), robust standard errors, M=20 multiple imputation sets, bootstrapped confidence intervals with 1000 replications
  3. c Adjusted for minimisation variables (baseline WOMAC pain score and surgical approach) and baseline utility for QALYs
  4. d Adjusted for minimisation variables, M=20 multiple imputation sets from main statistical analysis