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Table 4 Total hip replacement: differences in costs and outcomes between APEX randomised groups

From: Local anaesthetic wound infiltration in addition to standard anaesthetic regimen in total hip and knee replacement: long-term cost-effectiveness analyses alongside the APEX randomised controlled trials

  Difference (intervention – control)
  N Mean (95 % CI)
OUTCOMES    
QALYs    
QALY gain – available cases a 216 0.064 (0.018 to 0.110)
QALY gain – imputed data b 322 0.052 (0.011 to 0.094)
Primary clinical outcome    
WOMAC pain score improvement – available cases c 281 4.74 (0.95 to 8.54)
WOMAC pain score improvement – imputed data d 322 5.35 (1.33 to 9.34)
COST    
Initial inpatient stay    
Total of inpatient stay – available cases a 273 -£123 (£–364 to £118)
Total of inpatient stay – imputed data b 322 -£32 (£–349 to £285)
Secondary care after initial discharge    
Inpatient admissions – available cases a 236 £251 (£–114 to £617)
Inpatient admissions – imputed data b 322 £139 (£–174 to £452)
Outpatient visits – available cases a 287 -£2 (£–36 to £32)
Outpatient visits with – imputed data b 322 £4 (£–33 to £42)
Total secondary care cost – available cases a 231 £251 (£–136 to £639)
Total secondary care cost – imputed data b 322 £143 (£–184 to £471)
Community-based resources    
Total community-based costs – available cases a 202 -£4 (£–51 to £43)
Total community-based costs – imputed data b 322 -£34 (£–83 to £16)
Total NHS cost – complete NHS cost cases a 179 £15 (£–373 to £404)
Total NHS cost – imputed data b 322 £78 (£–404 to £560)
Personal social services (PSS)    
Total personal social services – available cases a 263 -£83 (£–289 to £123)
Total personal social services – imputed data b 322 -£164 (£–418 to £91)
Total NHS + PSS cost – complete NHS+PSS cost cases a 173 -£94 (£–634 to £446)
Total NHS + PSS cost – imputed data b 322 -£86 (£–634 to £462)
  1. a Adjusted for minimisation variables (baseline WOMAC pain score and surgical approach) and baseline utility for QALYs, robust standard errors
  2. b Adjusted for minimisation variables (and baseline utility for QALYs), robust standard errors, M=20 multiple imputation sets, bootstrapped confidence intervals with 1000 replications
  3. c Adjusted for minimisation variables (baseline WOMAC pain score and surgical approach) and baseline utility for QALYs
  4. d Adjusted for minimisation variables, M=20 multiple imputation sets from main statistical analysis