Table 3 Method comparison meta-analysis summary using numerical data

Reference technology

Mean (absolute range)

428 (402–453)

436 (418–474)

411 (384–437)

Median (IQR)

383 (249–555)

390 (254–565)

371 (241–537)

Pima

Mean (absolute range)

404 (373–425)

416 (388–444)

382 (351–412)

Median (IQR)

363 (234–524)

373 (242–534)

342 (221–507)

Agreement

Accuracy and Precision (cells/ul)

Mean bias (Pima - Reference)

−23

−23

−24

Mean bias (CI)

(−22;-25)

(−21; −25)

(−20; −28)

SD bias

106

93

126

Percentage similarity mean %

101

100

103

Percentage similarity SD %

87

67

116

Percentage similarity CV %

86

67

113

Percent bias (SD) >100 cells/μl

n = 11037, −3.26 % (26.4)

n = 7190, −3.1 % (22.5)

n = 3487, −3.54 % (32.3)

Concordance correlation (Pc)

0.914 (0.911, 0.917)

0.934 (0.931, 0.937)

0.874 (0.867, 0.881)

Strength of agreement

moderate

moderate

poor

Overall cell variance

<100 cells/ul^a

34

73

100-350 cesll/ul^b

38

51

350-500 cells/ul^b

33

57

>500 cells/ul^b

53

79

Percentage bias across all ranges^c

10 %

15 %