Table 2 Sensitivity and specificity values of microRNAs evaluated in discriminating metastatic and non-metastatic lymph nodes in FFPE and FNA biopsies from lymph node samples
microRNA | Sensitivity | Specificity | ||||
|---|---|---|---|---|---|---|
Cutoffa | Metastaticb | Macrometastases | Micrometastases | Isolated tumor cells | Non-metastatic | |
% (95 % CI) (n) | % (95 % CI) (n) | % (95 % CI) (n) | % (95 % CI) (n) | % (95 % CI) (n) | ||
FFPE samples | ||||||
miR-200a | 5.96 | 76.0 (54.5-89.8) (19/25) | 94.4 (70.6-99.7) (17/18) | 40.0 (7.3-82.9) (2/5) | 0 (0–80.2) (0/2) | 100 (71.7-100) (13/13) |
miR-200c | 2.33 | 88.0 (67.7-96.8) (22/25) | 100 (78.1-100) (18/18) | 80.0 (29.9-98.9) (4/5) | 0 (0–80.2) (0/2) | 100 (71.7-100)) (13/13) |
miR-203 | 1.96 | 100 (83.4-100) (25/25) | 100 (78.1-100) (18/18) | 100 (46.3-100) (5/5) | 100 (19.8-100) (2/2) | 100 (71.7-100) (13/13) |
miR-205 | 1.54 | 100 (83.4-100) (25/25) | 100 (78.1-100) (18/18) | 100 (46.3-100) (5/5) | 100 (19.8-100) (2/2) | 100 (71.7-100) (13/13) |
FNA samples classified by cytology | ||||||
miR-203 | 10 | 100 (91.5-100) (42/42) | 100 (91.5-100) (42/42) | N/A | N/A | 100 (94.9-100) (71/71) |
miR-205 | 10 | 100 (91.5-100) (42/42) | 100 (91.5-100) (42/42) | N/A | N/A | 100 (94.9-100) (71/71) |
FNA samples classified by histology | ||||||
miR-203 | 10 | 93.3 (81.7-98.6) (42/45) | 100 (91.5-100) (42/42) | 0 (0) (0/2) | 0 (0) (0/1) | 100 (94.7-100) (68/68) |
miR-205 | 10 | 93.3 (81.7-98.6) (42/45) | 100 (91.5-100) (42/42) | 0 (0) (0/2) | 0 (0) (0/1) | 100 (94.7-100) (68/68) |