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Table 3 Diagnostic performance of absolute 3-hour change in troponin I concentration

From: Identification of acute myocardial infarction in patients with atrial fibrillation and chest pain with a contemporary sensitive troponin I assay

  Cut-off Sensitivity Specificity PPV NPV
[ng/mL] (95 % CI) (95 % CI) (95 % CI) (95 % CI)
Absolute 3-h change in troponin I concentration
n=298, n=54 patients with MI type 1
Absolute 3-h change threshold optimized for:
Sum of sensitivity and specificity 0.011 0.83 (0.71-0.92) 0.90 (0.85-0.93) 0.64 (0.52-0.75) 0.96 (0.93-0.98)
Specificity 0.023 0.81 (0.69-0.91) 0.94 (0.91-0.97) 0.76 (0.63-0.86) 0.96 (0.92-0.98)
Absolute 3-h change in troponin I concentration and troponin I on admission above 99th percentile cut-off
n=66, n=46 patients with MI type 1
Absolute 3-h change threshold optimized for:
Sum of sensitivity and specificity 0.011 0.80 (0.66-0.91) 0.55 (0.32-0.77) 0.80 (0.66-0.91) 0.55 (0.32-0.77)
Specificity 0.023 0.80 (0.66-0.91) 0.70 (0.46-0.88) 0.86 (0.72-0.95) 0.61 (0.39-0.80)
Absolute 3-h change in troponin I concentration and troponin I on admission above unweighted optimized cut-off
n=61, n=44 patients with MI type 1
Absolute 3-h change threshold optimized for:
Sum of sensitivity and specificity 0.011 0.80 (0.65-0.90) 0.65 (0.38-0.86) 0.85 (0.71-0.94) 0.55 (0.32-0.77)
Specificity 0.023 0.80 (0.65-0.90) 0.82 (0.57-0.96) 0.92 (0.79-0.98) 0.61 (0.39-0.80)
Absolute 3-h change in troponin I concentration and troponin I on admission above specificity-optimized cut-off
n=41, n=36 patients with MI type 1
Absolute 3-h change threshold optimized for
Sum of sensitivity and specificity 0.011 0.75 (0.58-0.88) 0.80 (0.28-0.99) 0.96 (0.82-1) 0.31 (0.09-0.61)
Specificity 0.023 0.75 (0.58-0.88) 0.80 (0.28-0.99) 0.96 (0.82-1) 0.31 (0.09-0.61)