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Table 3 Distribution of selected keratin variants in the DILI and population control groups by subgroup

From: Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury

  Subgroup (#)   K8 G62C K8 I63V K8 A333A K8 R341H K8 V380I K8 G434S K8 V480I Totala
# 11/800 9/800 15/800 40/800 3/800 10/800 7/800 86/800
% 1.4 1.1 1.9 5.0 0.4 1.3 0.9 10.8
DILI Caucasian (577) # 10b 8 0 27b 3 0 3 54
% 1.7 1.4 0 4.7 0.5 0 0.5 9.4
African-American (87) # 0 0 13c 1 0 10c 4 15
% 0 0 14.9 1.2 0 11.5 4.6 17.2
Hispanic (88) # 0 0 2 9 0 0 0 11
% 0 0 2.3 10.2 0 0 0 12.5
Asian (25) # 0 0 0 1 0 0 0 2
% 0 0 0 4.0 0 0 0 8.0
Control Caucasian # 59/4,2961 30/4,2962 8/4,2983 259/4,2984,10 7/4,2975 1/3,9536 6/3,9807 406/4,300
% 1.4 0.7 0.2 6.0 0.2 0.03 0.2 9.4
African-American # 7/2,2001 3/2,2012 274/2,2013,8,9 35/2,2034,11 0/2,2035 169/2,0756,12,13 56/2,0867 388/2,203
% 0.3 0.1 12.4 1.6 0 8.1 2.7 17.6
Hispanic # - 1/121 1/1218 14/12110,11 - 0/12112 0/121 16/121
% - 0.8 0.8 11.6 - 0 0 13.2
Asian # - 0/286 0/2869 7/286 - 0/28613 0/286 7/286
% - 0 0 2.4 - 0 0 2.4
  1. Superscript numbers highlight comparisons between specific subgroups and the respective P values for these comparisons. For example, 1indicates a comparison of the frequency of the K8 G62C variant in Caucasian versus African-American controls. 1P <0.0001; 2P <0.002; 3P <0.0001; 4P <0.0001; 5P = 0.1; 6P <0.0001; 7P <0.0001; 8P <0.0001; 9P <0.0001; 10P <0.02; 11P <0.0001; 12P <0.0001; 13P <0.0001. aAmino acid-altering variants are summarized; bone patient carries two K8/K18 variants (K8 G62C+R341H); cone patient carries two K8/K18 variants (K8 A333A+G434S). DILI, drug-induced liver injury