Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury

Table 3 Distribution of selected keratin variants in the DILI and population control groups by subgroup

	Subgroup (#)		K8 G62C	K8 I63V	K8 A333A	K8 R341H	K8 V380I	K8 G434S	K8 V480I	Total^a
		#	11/800	9/800	15/800	40/800	3/800	10/800	7/800	86/800
		%	1.4	1.1	1.9	5.0	0.4	1.3	0.9	10.8
DILI	Caucasian (577)	#	10^b	8	0	27^b	3	0	3	54
	Caucasian (577)	%	1.7	1.4	0	4.7	0.5	0	0.5	9.4
	African-American (87)	#	0	0	13^c	1	0	10^c	4	15
	African-American (87)	%	0	0	14.9	1.2	0	11.5	4.6	17.2
	Hispanic (88)	#	0	0	2	9	0	0	0	11
	Hispanic (88)	%	0	0	2.3	10.2	0	0	0	12.5
	Asian (25)	#	0	0	0	1	0	0	0	2
	Asian (25)	%	0	0	0	4.0	0	0	0	8.0
Control	Caucasian	#	59/4,296¹	30/4,296²	8/4,298³	259/4,298^4,10	7/4,297⁵	1/3,953⁶	6/3,980⁷	406/4,300
	Caucasian	%	1.4	0.7	0.2	6.0	0.2	0.03	0.2	9.4
	African-American	#	7/2,200¹	3/2,201²	274/2,201^3,8,9	35/2,203^4,11	0/2,203⁵	169/2,075^6,12,13	56/2,086⁷	388/2,203
	African-American	%	0.3	0.1	12.4	1.6	0	8.1	2.7	17.6
	Hispanic	#	-	1/121	1/121⁸	14/121^10,11	-	0/121¹²	0/121	16/121
	Hispanic	%	-	0.8	0.8	11.6	-	0	0	13.2
	Asian	#	-	0/286	0/286⁹	7/286	-	0/286¹³	0/286	7/286
	Asian	%	-	0	0	2.4	-	0	0	2.4

Superscript numbers highlight comparisons between specific subgroups and the respective P values for these comparisons. For example, ¹indicates a comparison of the frequency of the K8 G62C variant in Caucasian versus African-American controls. ¹P <0.0001; ²P <0.002; ³P <0.0001; ⁴P <0.0001; ⁵P = 0.1; ⁶P <0.0001; ⁷P <0.0001; ⁸P <0.0001; ⁹P <0.0001; ¹⁰P <0.02; ¹¹P <0.0001; ¹²P <0.0001; ¹³P <0.0001. ^aAmino acid-altering variants are summarized; ^bone patient carries two K8/K18 variants (K8 G62C+R341H); ^cone patient carries two K8/K18 variants (K8 A333A+G434S). DILI, drug-induced liver injury

ISSN: 1741-7015