Table 4 Characteristics and sonographic follow-up of RAS-positive benign nodules
From: The variable phenotype and low-risk nature of RAS-positive thyroid nodules
Subject number | Sex | Age at study entry (years) | RAS mutation | Nodule size (mm) and parenchyma at study entry | FNA cytology at study entry | Previous or subsequent ultrasound | Duration of sonographic follow-up | Previous FNA cytology |
|---|---|---|---|---|---|---|---|---|
(date, size (mm), parenchyma) | (date, result) | |||||||
9 | Female | 52 | HRAS G12V | 11/2010, 18 × 5 × 11, <25 % Cystic | Benign | 02/2013, 16 × 11 × 9, Cystic (<25 %) | 3.9 years (no growth) | Not performed |
10/2014, 17 × 10 × 8, N/A |  | |||||||
10 | Female | 52 | HRAS Q61K | 03/2012, 16 × 14 × 9, Solid | Benign | 09/2008, 17 × 12 × 11, Solid | 3.4 years (no growth) | 11/2008, Benign cytology |
11/2008, 17 × 10 × 10, N/A |  | |||||||
01/2012, 16 × 15 × 9, Solid | ||||||||
11 | Female | 37 | KRAS G12V | 09/2011, 15 × 11 × 9, <25 % Cystic | Benign | - | N/A | Not performed |
12 | Female | 54 | KRAS G12V | 10/2010, 14 × 14 × 8, Solid | Benign | 07/1990, 13 × 12 × 7, N/A 10/1993, 14 × 12 × 8, N/A 05/1998, 15 × 13 × 8, Solid 06/1998, 15 × 13 × 8, Solid 10/1999, 15 × 13 × 7, Solid 07/2003, 15 × 14 × 7, Solid 07/2005, 14 × 14 × 8, Solid 10/2007, 15 × 14 × 7, Solid 01/2008, 13 × 12 × 7, Solid 08/2009, 14 × 13 × 8, Solid 09/2010, 16 × 15 × 9, Solid 07/2011, 16 × 13 × 7, Solid 01/2012, 15 × 15 × 7, Solid 01/2013, 16 × 15 × 8, Solid 07/2014, 15 × 14 × 9, Solid | 24.0 years (no growth) | 06/1998, Benign cytology |
13 | Female | 54 | NRAS Q61K | 04/2011, 15 × 12 × 11, <25 % Cystic | Benign | 05/2006, 15 × 9 × 9, Cystic (<25 %) 09/2006, 14 × 10 × 9, Cystic (<25 %) 06/2009, 12 × 11 × 11, Cystic (<25 %) 04/2011, 16 × 13 × 10, N/A 04/2012, 17 × 12 × 12, Cystic (<25 %) 06/2013, 15 × 12 × 10, Cystic (<25 %) | 7.0 years (no growth) | 09/2006, Benign cytology |
14 | Female | 30 | NRAS Q61R | 09/2011, 16 × 14 × 9, Solid | Benign | 08/2008, 13 × 13 × 8, Solid 12/2008, 13 × 13 × 9, Solid 07/2011, 15 × 14 × 8, N/A | 3.1 years (no growth) | 12/2008, Benign cytology |
15 | Female | 62 | NRAS Q61R | 01/2012, 17 × 14 × 12, Solid | AUS + Afirma GEC ‘Benign’ | N/A | N/A | 04/2012, AUS |
05/2012, Afirma GEC: ‘benign’ | ||||||||
16 | Female | 64 | HRAS G12V | 11/2010, 23 × 19 × 15, <25 % Cystic | AUS | N/A | N/A | 01/2011, Surgerya: benign histology |
17 | Male | 46 | HRAS Q61K | 03/2012, 56 × 45 × 33, Solid | Follicular neoplasm | N/A | N/A | 05/2012, Surgerya: benign histology |