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Fig. 1 | BMC Medicine

Fig. 1

From: Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy

Fig. 1

Number of CpG sites with significantly higher (a) or lower (b) DNA methylation in cases with PDR versus controls. Genes involved in retina and eye development (c), inflammation (d), diabetic complications (e), and oxidative stress (f) were among the ones with one or more CpG sites differentially methylated between cases with PDR and controls (q <0.05); data are presented as mean ± SD. Global DNA methylation is calculated as average DNA methylation based on all CpG sites in each region on the chip and shows no differences between cases with PDR compared with controls in mean methylation value based on gene regions (g) or regions in relation to nearest CpG island (h)

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