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Table 1 Effects of chemotherapy on tumor-infiltrating lymphocytes

From: Relevance of tumor-infiltrating lymphocytes in breast cancer

Drug Target Immunological effects and model used Reference
Gemcitabine Nucleoside analogue, prevents DNA replication Reduction in the number of MDSCs [126]
HER2/neu model; breast cancer [127, 128]
Mesothelioma and lung cancer models [48]
Reduction in MDSCs and Tregs when given with cyclophosphamide; CT26 colon carcinoma [49]
Reduction of Tregs in patients with pancreatic cancer
Cyclophosphamide DNA alkylation, cross-links DNA Induction of immunogenic cell death, IFN-I mediated activation of dendritic cells; EG7 thymoma, B16F10 melanoma [129]
Selective depletion of Tregs in MMTV-neu mice (breast cancer) [88]
Selective depletion of Tregs in colon carcinoma model [42]
Selective depletion of Tregs in melanoma model [130]
Reduction in MDSCs and Tregs when given with gemcitabine; CT26 colon carcinoma [48]
Paclitaxel Inhibition of mitosis through tubulin targeting Reduction in MDSC frequency and suppressive activity [131]
Reduction in Treg numbers and suppressive activity [52, 132]
Anthracyclines Multiple mechanisms Induction of immunogenic cell death; thymoma model, CT26 colon carcinoma [45]
Differentiation of CD11b+ LY6C+ APCs; MCA205 fibrosarcoma [133]
Elimination of MDSCs; 4 T1 and EMT6 breast tumor cell lines [134]
Oxaliplatin Cross-links DNA Induction of immunogenic cell death resulting in the activation of myeloid cells; thymoma/colon cancer model [45, 135]
Cisplatin Cross-links DNA Induce the accumulation of CD11c+ inflammatory dendritic cells; lung/colon carcinoma models [136]
Docetaxel Inhibition of mitosis through tubulin targeting Reduction in MDSC frequency and suppressive activity; B16 melanoma model [116]
5-aza-2′-deoxycytidine DNA methyltransferase inhibition Increased antigen presentation by tumor cells; 4 T1 breast cancer model [137]
Reduction in MDSCs and suppressive function; lung/prostrate carcinoma [138]
  1. APCs antigen-presenting cell, MDSC myeloid-derived suppressor cells, Tregs regulatory T cells