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Table 3 Tuberculosis (TB) prevalence stratified by patient characteristics and the number needed to screen (NNS) to identify one TB case in different risk groups

From: Rapid microbiological screening for tuberculosis in HIV-positive patients on the first day of acute hospital admission by systematic testing of urine samples using Xpert MTB/RIF: a prospective cohort in South Africa

Characteristic

Number of TB cases

TB prevalence, % (95 % CI)

P value

NNS (95 % CI)

All patients

139

32.6 (28.1–37.2)

-

3.1 (2.7–3.6)

Age (years)

 <35 (n = 199)

75

37.7 (30.8–44.6)

0.034

2.7 (2.2–3.2)

 ≥35 (n = 228)

64

28.1 (22.3–34.4)

 

3.6 (2.9–4.5)

Gender

 Male (n = 168)

49

29.2 (22.4–36.6)

0.260

3.4 (2.7–4.5)

 Female (n = 259)

90

34.8 (29.0–40.9)

 

2.9 (2.4–3.4)

HIV diagnosis

 New (n = 82)

34

41.5 (32.1–53.1)

0.055

2.4 (1.9–3.1)

 Existing (n = 345)

105

30.4 (25.0–35.1)

 

3.3 (2.8–4.0)

Previous history of TB

 No (n = 229)

88

38.4 (32.1–45.1)

0.005

2.6 (2.2–3.1)

 Yes (n = 196)

50

25.5 (19.6–32.2)

 

3.9 (3.1–5.1)

ART status

 Naive (n = 177)

71

40.1 (32.8–47.7)

0.007

2.5 (2.1–3.0)

 Any ART exposure (n = 250)

68

27.2 (21.8–33.2)

 

3.7 (3.0–4.6)

CD4 cell count (cells/μL)

 <100 (n = 160)

74

46.3 (38.3–54.3)

<0.001

2.2 (1.8–2.6)

 100–199 (n = 95)

35

36.8 (27.2–47.4)

 

2.7 (2.1–3.7)

 ≥200 (n = 169)

29

17.2 (11.8–23.7)

 

5.8 (4.2–8.5)

WHO anaemia grade

 No/mild anaemia (n = 144)

28

19.4 (13.3–26.9)

<0.001

5.2 (3.7–7.5)

 Moderate/severe anaemia (n = 277)

111

40.0 (34.3–46.1)

 

2.5 (2.2–2.9)

Sputum production

 No (n = 259)

85

32.8 (27.1–38.9)

0.814

3.0 (2.6–3.7)

 Yes (n = 161)

51

31.7 (24.6–39.5)

 

3.2 (2.5–4.1)

Current cough

 No (n = 223)

54

24.2 (18.7–30.4)

<0.001

4.1 (3.3–5.3)

 Yes (n = 201)

84

41.8 (34.9–48.9)

 

2.4 (2.0–2.9)

Cough duration

 <2 weeks (n = 389)

120

30.8 (26.3–35.7)

0.008

3.2 (2.8–3.8)

 ≥2 weeks (n = 34)

18

52.9 (35.1–70.2)

 

1.9 (1.4–2.8)

Current fever

 No (n = 360)

113

31.4 (26.6–36.5)

0.294

3.2 (2.7–3.8)

 Yes (n = 63)

24

38.1 (26.1–51.2)

 

2.6 (2.0–3.8)

Current night sweats

 No (n = 250)

65

26.0 (20.7–31.9)

0.001

3.8 (3.1–4.8)

 Yes (n = 174)

73

42.0 (34.5–49.7)

 

2.4 (2.0–2.9)

Recent weight loss

 No (n = 236)

62

26.3 (20.8–32.4)

0.002

3.8 (3.1–4.8)

 Yes (n = 189)

76

40.2 (33.2–47.6)

 

2.5 (2.1–3.0)

WHO symptom screen

 Negative (n = 36)

4

11.1 (3.1–26.1)

0.005

9.0 (3.8–32.3)

 Positive (n = 389)

134

34.5 (29.7–39.4)

 

2.9 (2.5–3.4)