Parameter | Symbol | Value | References |
---|---|---|---|
Duration of injecting career | 1/μ1 | 14 years | Fazito et al. global average [26] |
Mortality rate | μ2 | 0.0083 per year | Stoové et al. [27] |
Exit rate | μ | μ1 + μ2 per year |  |
Proportion at high risk, defined as the proportion of PWID experiencing unstable housing [16] | Vary η to calibrate | 0.17 | O’Keefe et al. [28] |
Duration at high risk | 12/κ | 13 months | O’Keefe et al. [28] |
Recruitment to high risk | η | Calibrated to proportion at high risk |  |
Infection risk factor of high-risk PWID compared to low-risk PWID | Γ | 3.6 | |
Infection rate | π | Calibrated to initial prevalence |  |
Proportion of infected who spontaneously clear | δ | 0.26 | Micallef et al. [24] |
Proportion treated who are cured (interferon-free DAAs, all genotypes) | α | 0.9 | |
Treatment duration (interferon-free DAAs, all genotypes) | 52/ω | 12 weeks | Lawitz et al. [10], Gane et al. [11], Poordad et al. [12], Chen et al. [32] |
Vaccine efficacy | ε | 30 %, 60 %, 90 % | Assumed |
Vaccine duration of protection | Â | Greater than the length of injecting career | Assumed |