TY - JOUR AU - Kheng, Sim AU - Muth, Sinoun AU - Taylor, Walter R. J. AU - Tops, Narann AU - Kosal, Khem AU - Sothea, Khon AU - Souy, Phum AU - Kim, Saorin AU - Char, Chuor Meng AU - Vanna, Chan AU - Ly, Po AU - Ringwald, Pascal AU - Khieu, Virak AU - Kerleguer, Alexandra AU - Tor, Pety AU - Baird, John K. AU - Bjorge, Steven AU - Menard, Didier AU - Christophel, Eva PY - 2015 DA - 2015/08/25 TI - Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency JO - BMC Medicine SP - 203 VL - 13 IS - 1 AB - Primaquine is used to prevent Plasmodium vivax relapse; however, it is not implemented in many malaria-endemic countries, including Cambodia, for fear of precipitating primaquine-induced acute haemolytic anaemia in patients with glucose-6-phosphate dehydrogenase deficiency (G6PDd). Reluctance to use primaquine is reinforced by a lack of quality safety data. This study was conducted to assess the tolerability of a primaquine regimen in Cambodian severely deficient G6PD variants to ascertain whether a weekly primaquine could be given without testing for G6PDd. SN - 1741-7015 UR - https://doi.org/10.1186/s12916-015-0441-1 DO - 10.1186/s12916-015-0441-1 ID - Kheng2015 ER -