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Table 2 Baseline characteristics in the two glucose-6-phosphate dehydrogenase groups

From: Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency

Parameter G6PD deficient G6PD normal P value
n = 18 n = 57
Age (years) 25 (5–56) 24 (7–63) 0.95
Aged <18 years 5 (27.8) 10 (17.5) 0.34
Male, female 15 (83.3), 3 48 (84.2), 9 0.93
Weight (kg) 54 (20–56) 53 (14–88) 0.83
Symptoms
 Headache 14 (77.8) 53 (92.9) 0.07
 Fever 14 (77.8) 48 (84.2) 0.53
 Chills 12 (66.7) 47 (82.5) 0.15
 Abdominal pain 4 (22.2) 28 (49.1) 0.04
 Nausea 3 (16.7) 14 (24.6) 0.48
 Cough 1 (5.6) 7 (12.3) 0.42
 Abnormal urine colour 9 (50) 7 (12.3) 0.001
Signs
 Mean (SD) temperature (°C) 37.8 (0.9) 38.6 (1.0) 0.002
 Mean (SD) pulse (mmHg) 92 (18.6) 96 (11.1) 0.32
 Mean (SD) systolic BP (mmHg) 105 (15.5) 110 (12.4) `0.17
 Mean (SD) diastolic BP (mmHg) 61 (11) 66 (10) 0.09
Normal conjunctival colour 18 (100) 56 (98.3) 0.57
Pale palms 1 (5.6) 5 (8.8) 0.66
Palpable liver 1 (5.6) 2 (3.5) 0.69
Palpable spleen 1 (5.6) 2 (3.5) 0.69
Haematological parameters
 G6PD activity (U/g Hb) 0.85 (0.1–1.5)a 12 (6.9–18.5) 0.000
 Normal haemoglobin 11 (61.1) 31 (54.4)  
 Heterozygous HbE 5 (27.8) 20 (35.1)  
 Homozygous HbE 0 1 (1.75)  
 Alpha/beta thalassaemia 1 (5.6) 5 (8.7) 0.4
 Haemoglobin (g/dL) 13.0 (9.6–16) 13.5 (9–16.3) 0.46
 Total white cell count ×103/μL 5.15 (1.4–8.3) 5.0 (1.1–11.5) 0.61
 Platelet count ×103/μL 126 (42–187) 99 (12–204) 0.26
Vivax parasitaemia/μL 6,420 (159–9326) 7,888 (220–59,542) 0.13
  1. Unless otherwise stated, continuous data are shown as median (range)
  2. Proportional data are shown as N (%)
  3. BP blood pressure, G6PD glucose-6-phosphate dehydrogenase HbE haemoglobin E, SD standard deviation
  4. asubstituting the two missing enzyme values with post D0 values: 0.9 (0.1–2.6) U/g Hb
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