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Table 3 Changes in haemoglobin concentrations in during the first 28 days of follow-up

From: Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency

Day G6PD deficient G6PD normal P G6PD deficient G6PD normal P G6PD deficient G6PD normal P
  Haemoglobin concentration (g/dL)   Changes in haemoglobin concentrations versus day 0   Fractional changes in haemoglobin concentrations versus day 0  
0 13.0 (9.6 to 16) 13.5 (9 to 16.3) 0.46   
1 11.2 (8.2 to 14.9) 12.4 (8.7 to 15.3) 0.041 – 1.5 (–4.0 to 1.1) – 0.8 (– 3.2 to 3.3) 0.059 –12.5 (– 27.1 to 8.7) – 6.5 (– 22.7 to 28.7) 0.028
2 10.8 (8.2 to 15.3) 12.4 (8.8 to 15.2) 0.006 – 1.7 (–5.0 to 0.6) – 1 (– 3.5 to 2.1) 0.047 –13.3 (– 31.2 to 4.1) – 7.4 (– 23.6 to 25.2) 0.029
3 10.9 (7.5 to 14.8) 12.8 (8.3 to 15.6) 0.0002 – 1.9 (–5.8 to 0.4) – 0.8 (– 2.6 to 2.9) 0.0003 –15.3 (– 39.2 to 3.6) – 6.1 (– 19.1 to 22.8) 0.0001
7 10.9 (8.9 to 13) 13 (9.5 to 15.7) 0.0001 – 2.2 (–4.9 to 0.8) –0.5 (– 2.2 to 2.8) 0.0002 – 16.3 (– 33.1 to 6.5) – 3.7 (– 17.5 to 23.3) 0.0002
14 11.4 (9.7 to 14.1) 12.8 (9.5 to 15.5) 0.0067 – 1.7 (–3.0 to 0.3) –0.5 (– 4.2 to 2.1) 0.005 – 12.9 (– 22.7 to 2.7) – 4 (– 25.7 to 18.1) 0.0035
21 12 (11 to 15.6) 13.3 (8.7 to 16.4) 0.039 – 0.6 (–2 to 1.6) 0.3 (– 3.5 to 2.1) 0.1 – 4.7 (– 15.1 to 14.6) 2.1 (– 24.3 to 16.8) 0.11
28 12.8 (10.9 to 15.4) 13.5 (9.5 to 16.1) 0.26 0.2 (–2 to 2.6) 0.3 (–2.3 to 2.7) 0.62 1.5 (– 13.6 to 27.1) 2.3 (– 15.8 to 21.2) 0.58
  1. All data are shown as median (range)
  2. G6PD glucose-6-phosphate dehydrogenase
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