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Table 3 Changes in haemoglobin concentrations in during the first 28 days of follow-up

From: Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency

Day

G6PD deficient

G6PD normal

P

G6PD deficient

G6PD normal

P

G6PD deficient

G6PD normal

P

 

Haemoglobin concentration (g/dL)

 

Changes in haemoglobin concentrations versus day 0

 

Fractional changes in haemoglobin concentrations versus day 0

 

0

13.0 (9.6 to 16)

13.5 (9 to 16.3)

0.46

–

–

 

–

–

 

1

11.2 (8.2 to 14.9)

12.4 (8.7 to 15.3)

0.041

– 1.5 (–4.0 to 1.1)

– 0.8 (– 3.2 to 3.3)

0.059

–12.5 (– 27.1 to 8.7)

– 6.5 (– 22.7 to 28.7)

0.028

2

10.8 (8.2 to 15.3)

12.4 (8.8 to 15.2)

0.006

– 1.7 (–5.0 to 0.6)

– 1 (– 3.5 to 2.1)

0.047

–13.3 (– 31.2 to 4.1)

– 7.4 (– 23.6 to 25.2)

0.029

3

10.9 (7.5 to 14.8)

12.8 (8.3 to 15.6)

0.0002

– 1.9 (–5.8 to 0.4)

– 0.8 (– 2.6 to 2.9)

0.0003

–15.3 (– 39.2 to 3.6)

– 6.1 (– 19.1 to 22.8)

0.0001

7

10.9 (8.9 to 13)

13 (9.5 to 15.7)

0.0001

– 2.2 (–4.9 to 0.8)

–0.5 (– 2.2 to 2.8)

0.0002

– 16.3 (– 33.1 to 6.5)

– 3.7 (– 17.5 to 23.3)

0.0002

14

11.4 (9.7 to 14.1)

12.8 (9.5 to 15.5)

0.0067

– 1.7 (–3.0 to 0.3)

–0.5 (– 4.2 to 2.1)

0.005

– 12.9 (– 22.7 to 2.7)

– 4 (– 25.7 to 18.1)

0.0035

21

12 (11 to 15.6)

13.3 (8.7 to 16.4)

0.039

– 0.6 (–2 to 1.6)

0.3 (– 3.5 to 2.1)

0.1

– 4.7 (– 15.1 to 14.6)

2.1 (– 24.3 to 16.8)

0.11

28

12.8 (10.9 to 15.4)

13.5 (9.5 to 16.1)

0.26

0.2 (–2 to 2.6)

0.3 (–2.3 to 2.7)

0.62

1.5 (– 13.6 to 27.1)

2.3 (– 15.8 to 21.2)

0.58

  1. All data are shown as median (range)
  2. G6PD glucose-6-phosphate dehydrogenase