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Table 4 Changes in laboratory parameters over time

From: Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency

Parameter G6PDd G6PDn P G6PDd G6PDn P G6PDd G6PDn P G6PDd G6PDn P
  D0 D7 D28 D56
Reticulocyte count (%) 1.7 1.3 0.051 3 1.9 0.0009 1.4 1.5 0.056 1 1.2 0.98
(0.6–3.8) (0.5–4.5) (1.6–3) (0.6–7) (0.9–4.8) (0.3–6) (0.5–2.4) (0.4–2.6)
Plasma haemoglobin (g/dL) 0.1 0.085 0.3 0.05 0.05 0.81 0.03 0.04 0.75 0.08 0.08 0.9
(0.01–13.5) (0.01–0.71) (0.02–0.46) (0–0.27) (0.01–0.13) (0–0.28) (0.04–0.09) (0–0.24)
Haptoglobin (g/L) 0.34 0.59 0.21 0.35 0.72 0.006 0.69 0.98 0.03 0.54 0.87 0.029
(0–1.48) (0–2.16) (0.09–1.07) (0.1–1.83) (0.16–1.19) (0.04–2.32) (0.08–1.25) (0.06–2.22)
Low haptoglobina 8/16 14/56 0.056 5/14 8/57 0.11 2/14 3/52 0.28 5/14 4/49 0.02
(50) (25) (35.7) (14.1) (14.3) (5.8) (35.7) (8.2)
LDH (IU/L) 308 231 0.01 350 196 0.0002 319.5 183.5 0.005 296.5 181 0.008
(127–800) (23–611) (178–700) (58–783) (121–619) (37–593) (154–746) (118–522)
High LDHa 13/17 18/56 0.002 12/15 12/57 0.000 10/14 7/52 0.001 8/14 7/49 0.002
(76.5) (32.1) (80) (21.1) (71.4) (13.5) (57.1) (14.3)
Unconjugated bilirubin (mg/L) 2.5 3.75 0.63 1.7 1.7 0.9 1.4 1.4 0.66 1.45 1.5 0.59
(0.6–9.8) (0.5–14.3) (0.4–4.8) (0.19–3.1) (0.7–3.6) (0.2–4.3) (0.6–3.4) (0.5–4.3)
Creatinine (μmol/L) 58 74 0.003 58 63 0.13 54.5 60.5 0.29 54.5 58 0.32
(28–86) (35–90) (28–83) (28–85) (19–82) (27–99) (24–80) (26–84)
  1. anumerator/denominator (%)
  2. Low below the lower limit of normal for haptoglobin LLN (0.3 g/L), High above the upper limit of normal for LDH (255 IU/L)
  3. G6PDd glucose-6-phosphate dehydrogenase deficient, G6PDn glucose-6-phosphate dehydrogenase normal, LDH lactate dehydrogenase