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Table 1 Baseline characteristics of the patients in the analysis

From: Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data

Baseline characteristics

AL (2002–2012)

AS-AQ (1999–2012)

DP (2003–2011)

Total (1999–2012)

Patients (N)

13,664 (46.3 %)

11,337 (38.4 %)

4,492 (15.2 %)

29,493

Female

6,437 (47.1 %)

5,322 (46.9 %)

2,123 (47.3 %)

13,882 (47.1 %)

Age

    

Mean age ± SD (years)

7.4 ± 9.22

6.6 ± 8.60

4.9 ± 7.51

6.7 ± 8.78

<1 year

795 (5.8 %)

842 (7.4 %)

447 (10.0 %)

2,084 (7.1 %)

1 to <5 years

7,183 (52.6 %)

6,324 (55.8 %)

3,185 (70.9 %)

16,692 (56.6 %)

5 to <12 years

3,184 (23.3 %)

2,357 (20.8 %)

432 (9.6 %)

5,973 (20.3 %)

≥12 years

2,478 (18.1 %)

1,801 (15.9 %)

427 (9.5 %)

4,706 (16.0 %)

Geographic region

    

East Africa

6,040 (44.2 %)

2,920 (25.8 %)

2,229 (49.6 %)

11,189 (37.9 %)

West Africa

6,481 (47.4 %)

6,749 (59.5 %)

1,302 (29.0 %)

14,532 (49.3 %)

Central Africa

483 (3.5 %)

758 (6.7 %)

174 (3.9 %)

1,415 (4.8 %)

South Africa

660 (4.8 %)

910 (8.0 %)

787 (17.5 %)

2,357 (8.0 %)

Transmission settings

    

High

4,836 (35.4 %)

4,062 (35.8 %)

1,876 (41.8 %)

10,774 (36.5 %)

Low/moderate

8,828 (64.6 %)

7,275 (64.2 %)

2,616 (58.2 %)

18,719 (63.5 %)

Enrolment clinical parameters

    

Mean body weight ± SD (kg)

21.2 ± 16.23

19.5 ± 15.26

16.3 ± 13.72

19.8 ± 15.59

Median parasitaemia (IQR)

19,260 (5,930–48,260)

20,000 (6,080–52,480)

25,540 (8,320–59,830)

20,200 (6,320–51,520)

Parasitaemia >100,000/μL

8.4 % (1,152/13,664)

10.7 % (1,209/11,337)

11.7 % (527/4,492)

9.8 % (2,888/29,493)

Mean haemoglobin ± SD (g/dl)

10.3 ± 2.17

9.7 ± 2.10

9.6 ± 1.86

9.9 ± 2.11

Gametocytes presence

8.2 % (868/10,649)

11.1 % (821/7,428)

9.1 % (394/4,325)

9.3 % (2,083/22,402)

Elevated temperature (>37.5 °C)

61.9 % (7,861/12,691)

67.3 % (7,461/11,092)

63.7 % (2,814/4,419)

64.3 % (18,136/28,202)

Anaemia

    

Moderate

44 % (4,246/9,650)

48.6 % (3,761/7,734)

52.7 % (2,159/4,095)

47.3 % (10,166/21,479)

Severe

6.9 % (666/9,650)

10.1 % (780/7,734)

7.5 % (306/4,095)

8.2 % (1,752/21,479)

  1. AL, artemether-lumefantrine; AS-AQ, artesunate-amodiaquine; DP, dihydroartemisinin-piperaquine