Univariable analysis | Multivariable analysisc | |||||
---|---|---|---|---|---|---|
Variable | N (n)a | Random effectsb | Crude OR (95 % CI) | P value | Adjusted OR (95 % CI) | P value |
Baseline parasitaemia (2-fold rise) | 27,496 (1,853) | 2.31 | 1.30 (1.26–1.34) | <0.001 | 1.27 (1.24–1.31) | <0.001 |
Baseline anaemia | ||||||
Non-anaemic (reference)d | 8,838 (544) | 2.14 | 1 | - | - | - |
Moderate | 9,652 (714) | 1.07 (0.94–1.22) | 0.274 | 1.07 (0.94–1.22) | 0.289 | |
Severe | 1,668 (124) | 1.24 (0.99–1.55) | 0.056 | 1.33 (1.06–1.67) | 0.014 | |
Unknown | 7,338 (471) | - | - | - | - | |
Gametocytes presence | ||||||
No (reference) | 18,672 (1,358) | 2.08 | 1 | - | - | - |
Yes | 1,979 (102) | 0.95 (0.74–1.2) | 0.650 | - | - | |
Febrile on presentation (temperature >37.5 °C) | ||||||
No (reference) | 9,355 (433) | 2.06 | 1 | - | - | - |
Yes | 17,217 (1,412) | 1.72 (1.52–1.95) | <0.001 | 1.46 (1.28–1.66) | <0.001 | |
Gendere | ||||||
Female (reference) | 12,873 (835) | 2.22 | 1 | - | - | - |
Male | 13,995 (982) | 1.11 (1.00–1.23) | 0.052 | - | - | |
Age category | ||||||
≥12 years (reference) | 4,245 (202) | 2.22 | 1 | - | - | - |
<1 year | 2,014 (139) | 1.89 (1.40–2.57) | <0.001 | 1.49 (1.09–2.05) | 0.013 | |
1 to <5 years | 15,677 (1,176) | 1.94 (1.52–2.46) | <0.001 | 1.54 (1.21–1.97) | 0.001 | |
5 to <12 years | 5,528 (334) | 1.49 (1.20–1.85) | <0.001 | 1.25 (1.00–1.56) | 0.048 | |
Transmission settings | ||||||
High (reference) | 10,368 (455) | 2.12 | 1 | - | - | - |
Low/moderate | 17,128 (1,398) | 1.50 (0.88–2.55) | 0.135 | 1.88 (1.09–3.24) | 0.024 | |
Treatmentf | ||||||
DP (reference) | 4,420 (340) | 2.12 | 1 | - | - | - |
AL | 12,255 (729) | 1.19 (1.00–1.42) | 0.050 | 1.21 (1.01–1.44) | 0.040 | |
ASAQ-FDC | 4,997 (246) | 0.94 (0.75–1.19) | 0.619 | 0.90 (0.71–1.14) | 0.388 | |
ASAQ-coblistered NFDC | 1,574 (167) | 1.80 (0.84–3.85) | 0.130 | 1.87 (0.86–4.04) | 0.113 | |
ASAQ-loose NFDC | 4,250 (371) | 1.62 (1.18–2.22) | 0.003 | 1.46 (1.05–2.01) | 0.022 |