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Table 2 Parameters of the economic model

From: Extending the elderly- and risk-group programme of vaccination against seasonal influenza in England and Wales: a cost-effectiveness study

Parameter Estimate Uncertainty Source
Relative risk of consulting a GP in a risk group 1.51 Normal (μ = 1.51, sd = 0.18) Flusurvey (http://flusurvey.org.uk/) cohort [14]
Cost of vaccination 15.85 Triangular (vertices 12, 15.55, 20) Personal communication (Department of Health)
Febrile cases 0.406 Triangular on [0.309–0.513] Review of volunteer studies [13]
All ARI cases 0.645 Triangular on [0.546–0.733] Review of volunteer studies [13]
QALY loss per non-fatal ILI case 7.49 × 10-3 Bootstrap from data on H1N1 pdm Van Hoek et al. [21]
QALY loss per non-fatal ARI case 1.01 × 10-3 Normal (μ = 1.01 × 10-3, sd = 8.35 × 10-5) Camacho et al. [14]
QALY loss per hospitalisation 0.018 Normal (mu=0.018, sigma=0.0018) Siddiqui et al. [22]
Hospital cost (per episode) £840 Lognormal (normal μ = 839, normal σ = 192.1) Baguelin et al. [7]
GP cost (per consultation) £37 Lognormal (normal μ = 37, normal σ = 8.4) Baguelin et al. [7]
  1. Values of parameters used in the economic model and their associated uncertainty. As part of the probabilistic sensitivity analysis, more uncertainty is added by using the distributions of estimates from Cromer et al. [11] rather than the mean estimates when estimating the risk of different health outcomes following one influenza infection
  2. GP, General practitioner; ARI, Acute (non-influenza-like) respiratory infections; ILI, Influenza-like illness; QALY, Quality-adjusted life year