Table 4 Cox regression analysis of risk of new Plasmodium falciparum infection by day 28

Univariable model

Day 7 lumefantrine concentration (log₂)

All^b

2,528

180

0.79 (0.72 to 0.87)

<0.001

 Venous plasma

1,336

40

0.65 (0.56 to 0.76)

<0.001

 Capillary blood^b

663

130

0.87 (0.78 to 0.98)

0.002

 Venous blood

529

10

0.82 (0.33 to 2.07)

0.619

Age (years)

2,528

180

0.95 (0.92 to 0.99)

0.009

Age category

  < 1 year

73

9

3.51 (1.16 to 10.59)

0.026

 1–4 years

1,004

148

5.01 (2.06 to 12.21)

<0.001

 5–11 years

540

14

2.95 (1.17 to 7.39)

0.021

 12+ years

911

9

Reference

Sex (female)

2,528 (1,157)

180 (93)

1.13 (0.84 to 1.51)

0.428

WAZ

1,076

157

0.86 (0.76 to 0.97)

0.015

Underweight^c

1,076 (192)

157 (37)

1.22 (0.84 to 1.79)

0.299

Transmission intensity areas (TIAs)

 Very low/low^d

557

9

0.17 (0.05 to 0.51)

0.002

 Moderate

721

17

0.16 (0.05 to 0.56)

0.004

 High

1,070

154

Reference

Multivariable model

Day 7 lumefantrine concentration (log₂)^e

2,528

180

0.70 (0.63 to 0.78)

<0.001

Location/transmission intensity area (TIA)

Very low/low/moderate TIA

1,304

26

0.22 (0.06 to 0.82)

0.024

High TIA

  < 1 year

57

9

0.91 (0.27 to 3.05)

0.882

 1–4 years

703

138

1.35 (0.49 to 3.74)

0.565

 5+ years

464

7

Reference