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Table 3 Comparison of the effects of statin therapy on coronary atherosclerosis indices in subgroups of trials recruiting subjects with and without ACS

From: Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies

 

Without ACS

With ACS

SMD

95 % CI

P value

SMD

95 % CI

P value

Plaque volume

−0.175

−0.334, −0.015

0.032

−0.080

−0.258, 0.099

0.382

Lumen volume

−0.033

−0.121, 0.056

0.469

−0.007

−0.148, 0.134

0.919

External elastic membrane volume (mm3)

−0.065

−0.154, 0.024

0.150

−0.121

−0.263, 0.020

0.093

Fibrous volume (mm3)

−0.010

−0.053, 0.133

0.888

0.027

−0.243, 0.297

0.844

Fibro-fatty volume

−0.395

−0.824, 0.034

0.071

0.008

−0.312, 0.328

0.961

Dense calcium volume

−0.119

−0.304, 0.065

0.206

−0.137

−0.266, −0.007

0.038

Necrotic core volume

0.271

−0.013, 0.555

0.062

0.074

−0.055, 0.203

0.261

  1. ACS, acute coronary syndrome; CI, confidence interval; SMD, standardized mean difference