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Fig. 3 | BMC Medicine

Fig. 3

From: Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Fig. 3

Stratification of the analysis by hepatitis infection status and liver function score. (a) O-PLS score plot including HCC cases infected by HBV or HCV (n = 37) and matched controls (n = 72), R2 = 45 % and Q2 = 34 %, and the metabolic signature. (b) O-PLS score plot including HCC cases with HBV/HCV free (n = 77) and matched controls (n = 150), R2 = 28 % and Q2 = 12 %, and the metabolic signature colored for correlation after significance to ANOVA tests (Benjamini-Hochberg multiple corrected). (c) O-PLS score plot including HCC cases with liver function score ≥1 (n = 80) and matched controls (n = 155), R2 = 58 % and Q2 = 43 %, and the metabolic signature colored for correlation after significance to ANOVA tests (Benjamini-Hochberg multiple corrected). The validations of the O-PLS models are presented in Additional file 1: Figure S2. 1, CH3 bond of lipids mainly VLDL; 1’, CH3 bond of lipids, mainly LDL; 2, Leucine; 3, Isoleucine; 4, Valine; 5, Propylene glycol; 6, Ethanol; 7, CH2 bond of lipids; 8, CH2-CH2-COOC bond of lipids; 9, Acetate; 10, CH2-CH = bond of lipids; 11, N-acetyl glycoproteins; 12, Acetone and CH2-CH2-COOC bond of lipids; 13, Glutamate; 14, Glutamine; 15, citrate; 16 = CH-CH2-CH = bond of lipids; 17, Choline; 18, Glucose; 19, Lipid O-CH2; 20, mannose and lipids; 21, CH = CH bond of lipids; 22, Tyrosine; 23 Phenylalanine. Phc, Phosphocholine

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