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Table 2 Sickle SCAN™ results compared to known genotypes

From: Validation of a novel point of care testing device for sickle cell disease

Number of samples

Sickle SCAN™

Genotype

23

S

20 confirmed HbSS

2 confirmed HbSβ0

1 confirmed HbSβa,b

14

SC

14 confirmed HbSC

21

AS

17 confirmed or previously known HbAS (trait)

3 confirmed HbSS with recent transfusionb

1 confirmed HbSDc

3

AC

3 persons with known HbAC

8

A

8 persons known without HbC or HbSd

2

C

3 confirmed with HbCC

  1. aAs per the purposeful test design, persons with HbSβ+ appear as HbSS using this test. This sample contained 24 % hemoglobin A; bpersons with HbSS that were found to have been transfused based on electrophoresis and further investigation after testing; cerroneous result of HbAS in person with HbSD; dpersons noted to have HbA were known β-thalassemia carriers in two cases. Definitive electrophoresis was not performed in six cases but newborn screening reports were reportedly normal in all six persons