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Fig. 3 | BMC Medicine

Fig. 3

From: RNY-derived small RNAs as a signature of coronary artery disease

Fig. 3

s-RNYs are released in the extracellular milieu by foam cells and in the peripheral blood of two mouse models for atherosclerosis. RT-qPCR of the indicated s-RNYs in the blood plasma of ApoE −/− (a) or Ldlr −/− (b) mice or control (wt). Mice were fed with either chow diet or high cholesterol diet. Data were normalized by using cel-miR-39 and are presented as mean and standard deviation (n per group = 8 for (a) and n per group = 5 for (b)). c RT-qPCR analysis of the indicated s-RNYs from the medium of bone marrow-derived macrophages (n per group = 4). d RT-qPCR analysis of the indicated s-RNYs from the medium of CRL 2797 cells (smooth muscle cells) incubated for 28 h with 0.25 μM thapsigargin in combination with the indicated concentration of acetylated LDL and control. The data were normalized by cel-miR-39 and are presented as mean and standard deviation (n per group = 4). e RT-qPCR of s-RNY1-5p in the blood plasma of CD68-hBcl-2 ApoE −/− or control (ApoE −/−). Data were normalized by cel-miR-39 and are presented as mean and standard deviation (n per group = 4). Student’s t-test: *P <0.05, **P <0.01

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