Table 5 Comparative analysis between s-RNY1-5p and selected coronary artery disease-associated miRNAs in the derivation cohort

Normalization by cel miR-39

2^-ΔΔCt in CAD

2^-ΔΔCt in CTL

ROC Area

P value

Std. Error

95 % Confidence interval

 sRNY1-5p

12.15861132

1.506803056

0.919

<0.0001

0.02286

0.8742–0.9639

 miR17

0.804077414

0.920930566

0.5687

0.1898

0.0501

0.4705–0.6669

 miR92a

4.91098005

0.976527138

0.5919

0.07926

0.05539

0.4833–0.7005

 miR126

2.592316951

1.265612624

0.6784

0.0006643

0.04854

0.5832–0.7735

 miR133

4.765530301

1.095526208

0.5965

0.06534

0.05355

0.4915–0.7015

 miR145

4.239215843

0.979840396

0.5083

0.8735

0.05351

0.4034–0.6132

 miR155

8.677582108

1.039014581

0.6255

0.01659

0.05367

0.5203–0.7307

 miR208a

5.554050756

1.058798935

0.7246

<0.0001

0.0484

0.6297–0.8195

Normalization by RNU48

2^-ΔΔCt in CAD

2^-ΔΔCt in CTL

ROC Area

P value

Std. Error

95 % Confidence interval

 sRNY1-5p

13.95354052

1.069518668

0.8341

<0.0001

0.0442

0.7475–0.9208

 miR17

1.084053274

0.949856557

0.5428

0.414

0.05115

0.4425–0.6431

 miR92a

1.20101817

1.033002128

0.7865

<0.0001

0.03945

0.7092–0.8639

 miR126

1.44021571

1.072261942

0.509

0.8636

0.06102

0.3894–0.6286

 miR133

1.334960926

1.126558473

0.5608

0.2459

0.05328

0.4563–0.6652

 miR145

1.52987889

0.939525323

0.749

<0.0001

0.04181

0.6670–0.8310

 miR155

0.891246591

1.064118053

0.527

0.6064

0.05249

0.4241–0.6299

 miR208a

0.247755721

1.009457364

0.6772

0.0007879

0.04678

0.5855–0.7689

Normalization by miR-24

2^-ΔΔCt in CAD

2^-ΔΔCt in CTL

ROC Area

P value

Std. Error

95 % Confidence interval

 sRNY1-5p

11.26524945

0.975729203

0.9382

<0.0001

0.0236

0.8919–0.9845

 miR17

1.509090429

0.934815204

0.6605

0.002226

0.04591

0.04591

 miR92a

2.551324286

0.952726947

0.767

<0.0001

0.04154

0.6856–0.8484

 miR126

1.754084858

1.200874169

0.5595

0.2568

0.05284

0.4559–0.6631

 miR133

2.155706321

0.928731186

0.5996

0.05769

0.05292

0.4958–0.7033

 miR145

3.099747057

1.041255052

0.7506

<0.0001

0.04349

0.6653–0.8359

 miR155

1.828043362

1.008436566

0.5143

0.7853

0.05613

0.4043–0.6243

 miR208a

1.334878917

1.120233854

0.6398

0.008176

0.0532

0.5355–0.7441