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Table 5 Comparative analysis between s-RNY1-5p and selected coronary artery disease-associated miRNAs in the derivation cohort

From: RNY-derived small RNAs as a signature of coronary artery disease

Normalization by cel miR-39 2-ΔΔCt in CAD 2-ΔΔCt in CTL ROC Area P value Std. Error 95 % Confidence interval
 sRNY1-5p 12.15861132 1.506803056 0.919 <0.0001 0.02286 0.8742–0.9639
 miR17 0.804077414 0.920930566 0.5687 0.1898 0.0501 0.4705–0.6669
 miR92a 4.91098005 0.976527138 0.5919 0.07926 0.05539 0.4833–0.7005
 miR126 2.592316951 1.265612624 0.6784 0.0006643 0.04854 0.5832–0.7735
 miR133 4.765530301 1.095526208 0.5965 0.06534 0.05355 0.4915–0.7015
 miR145 4.239215843 0.979840396 0.5083 0.8735 0.05351 0.4034–0.6132
 miR155 8.677582108 1.039014581 0.6255 0.01659 0.05367 0.5203–0.7307
 miR208a 5.554050756 1.058798935 0.7246 <0.0001 0.0484 0.6297–0.8195
Normalization by RNU48 2-ΔΔCt in CAD 2-ΔΔCt in CTL ROC Area P value Std. Error 95 % Confidence interval
 sRNY1-5p 13.95354052 1.069518668 0.8341 <0.0001 0.0442 0.7475–0.9208
 miR17 1.084053274 0.949856557 0.5428 0.414 0.05115 0.4425–0.6431
 miR92a 1.20101817 1.033002128 0.7865 <0.0001 0.03945 0.7092–0.8639
 miR126 1.44021571 1.072261942 0.509 0.8636 0.06102 0.3894–0.6286
 miR133 1.334960926 1.126558473 0.5608 0.2459 0.05328 0.4563–0.6652
 miR145 1.52987889 0.939525323 0.749 <0.0001 0.04181 0.6670–0.8310
 miR155 0.891246591 1.064118053 0.527 0.6064 0.05249 0.4241–0.6299
 miR208a 0.247755721 1.009457364 0.6772 0.0007879 0.04678 0.5855–0.7689
Normalization by miR-24 2-ΔΔCt in CAD 2-ΔΔCt in CTL ROC Area P value Std. Error 95 % Confidence interval
 sRNY1-5p 11.26524945 0.975729203 0.9382 <0.0001 0.0236 0.8919–0.9845
 miR17 1.509090429 0.934815204 0.6605 0.002226 0.04591 0.04591
 miR92a 2.551324286 0.952726947 0.767 <0.0001 0.04154 0.6856–0.8484
 miR126 1.754084858 1.200874169 0.5595 0.2568 0.05284 0.4559–0.6631
 miR133 2.155706321 0.928731186 0.5996 0.05769 0.05292 0.4958–0.7033
 miR145 3.099747057 1.041255052 0.7506 <0.0001 0.04349 0.6653–0.8359
 miR155 1.828043362 1.008436566 0.5143 0.7853 0.05613 0.4043–0.6243
 miR208a 1.334878917 1.120233854 0.6398 0.008176 0.0532 0.5355–0.7441
  1. CAD, Coronary artery disease; CTL, Control; ROC, Receiver operating curve