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Fig. 1 | BMC Medicine

Fig. 1

From: PCSK9 inhibition: the way forward in the treatment of dyslipidemia

Fig. 1

a. PCSK9-mediated degradation of low-density lipoprotein receptor (LDLR). A complex of low-density lipoprotein cholesterol (LDL-C), LDLR, and PCSK9 is internalized into hepatocytes within clathrin-coated pits and subsequently undergoes lysosomal degradation. b. PCSK9 inhibition. Monoclonal antibodies bound to PCSK9 prevent the association between PCSK9 and LDLR. LDLR binds and internalizes LDL-C particles, which are then degraded in the lysosome, whereas the LDLR is recycled back to the plasma membrane. Re-use kindly permitted by the American Society for Biochemistry and Molecular Biology, Inc. Figure derived from The PCSK9 decade [13]

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