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Table 1 Characteristics of included studies

From: Comparison of registered and published outcomes in randomized controlled trials: a systematic review

Authors Journal and publication year Publication dates of included trials Trials registries used Description of included trials Trials included in outcome consistency assessment Date of initial registry search Method of identifying included studies Used prospectively registered outcomes in discrepancy analysis Method of characterizing outcome discrepancies Subgroup analyses Additional comparisons between registry and manuscript
Anand et al. [16] Intensive Care Med. 2014 2005–2011 ClinicalTrials.gov, ISRCTN, anzctr.org.au Critical care trials 55 Unknown Publication search Yes Not applicable Journals following ICMJE recommendations Sample size
Bourgeois et al. [17] Ann Intern Med. 2010 Not available ClinicalTrials.gov Trials of anticholestermics, antidepressants, antipsychotics, proton pump inhibitors, vasodilators 85 31 August 2009 Registry search No Not applicable Funding source None
Chahal et al. [18] Am J Sports Med. 2012 Not available ClinicalTrials.gov Orthopedic sports medicine trials 20 Unknown Registry search No Modified version of Chan’s classification None Sample size, inclusion criteria
Ewart et al. [15] Ann Fam Med. 2009 2006–2007 ClinicalTrials.gov, ISRCTN, anzctr.org.au, national register for included trials Trials in high-impact journals 110 Unknown Publication search No Chan None None
Gandhi et al. [19] BMC Musculoskelet Disord. 2011 1999–2010 ClinicalTrials.gov Trials related to orthopedic trauma 20 July 2010 Registry search No Chan Funding source Sample size
Hannink et al. [20] Ann Surg. 2013 2007–2012 ClinicalTrials.gov, ISRCTN, anzctr.org.au, “Other” Trials assessing surgical interventions 152 Unknown Publication search Yes Chan General medical vs surgical journals None
Hartung et al. [21] Ann Intern Med. 2014 Not available ClinicalTrials.gov Random sample of phase 3 or 4 trials completed before January 2009 with results available in ClinicalTrials.gov 110 15 February 2011 Registry search No Not applicable None Results, adverse events
Huić et al. [22] PLoS One. 2011 2005–2005 ClinicalTrials.gov Trials in ICMJE member journals 152 Unknown Publication search Yes Chan None Title, start date, trial methods, sample size
Hutfless et al. [23] Abstract from American Gastroenterological Association 2013 meeting Not available ClinicalTrials.gov Trials of Crohn’s disease medications 25 July 2010 Unknown No Not applicable None None
Jones et al. [24] Ann Emerg Med. 2012 2008–2011 ClinicalTrials.gov, ISRCTN, WHO portal, national register for included trials Trials published in emergency medicine journals 57 Unknown Publication search Yes Chan None None
Khan et al. [25] Arthritis Rheum. 2012 2002–2007 ClinicalTrials.gov Trials of drug therapy for rheumatoid arthritis 6 Unknown Publication search No Not applicable None None
Killeen et al. [26] Ann Surg. 2014 2009–2010 ClinicalTrials.gov, ISRCTN, WHO portal, national register for included trials Trials from surgical journals 108 Unknown Publication search No Chan None None
Li et al. [27] Scand J Gastroenterol. 2013 2009–2012 “Registries accepted by the ICMJE” Gastroenterology trials 155 Unknown Publication search No Chan General medical vs gastroenterology & hepatology journals None
Liu et al. [28] BMJ Open. 2013 Not available WHO registry portal plus Korean Clinical Research Information Service Trials of traditional Chinese medicine 65 July 2012 Registry search No Not applicable None Sample size, study methods
Mathieu et al. [7] JAMA. 2009 2008 ClinicalTrials.gov, ISRCTN, WHO portal, national register for included trials Cardiology, rheumatology, and gastroenterology trials in high-impact general medical and specialty journals 147 Unknown Publication search Yes Chan General medical vs specialty journals None
Mathieu et al. [29] Joint Bone Spine. 2012 2006–2008 ClinicalTrials.gov, ISRCTN Trials on rheumatoid arthritis, osteoarthritis, and spondyloarthropathies 40 Unknown Publication search No Not applicable None None
Milette et al. [30] J Psychosom Res. 2011 2008–2009 ClinicalTrials.gov, ISRCTN, WHO portal, national register for included trials Trials in psychosomatic and behavioral health journals 1 Unknown Publication search Yes Not described None None
Nankervis et al. [31] J Invest Dermatol. 2012 2007–2011 WHO portal Eczema trials from the Global Resource for Eczema Trials (GREAT) database 8 Unknown Publication search Yes Differences in primary and published outcomes or outcome timing None None
Pinto et al. [32] Phys Ther. 2013 2009 ClinicalTrials.gov, ISRCTN, WHO portal, anzctr.org.au, national register for included trials Physical therapy trials indexed in the Physiotherapy Evidence Database (PEDro) 62 Unknown Publication search No Chan None None
Rosenthal et al. [33] Ann Surg. 2013 2010 ClinicalTrials.gov, ISRCTN, WHO portal Trials from high impact general surgical journals 51 Unknown Publication search No Chan Funding source, registration timing Trial methods, sample size, analytical plan
Ross et al. [8] PLoS Med. 2009 Not available ClinicalTrials.gov Random sample of phase 2–4 trials registered in ClinicalTrials.gov and completed by June 2007 198 Unknown Registry search No Not applicable None None
Smith et al. [34] J Arthroplasty. 2012 2006–2011 ClinicalTrials.gov Arthroplasty trials 25 July 2010 Registry search No Chan Funding source Sample size
Smith et al. [9] Pain. 2013 2002–2011 ClinicalTrials.gov Trials from the Repository of Registered Analgesic Clinical Trials 79 1 December 2011 Registry search No Chan Funding source, trial phase Analytical plan, missing data plan
Vera-Badillo et al. [35] Ann Oncol. 2013 1995–2011 ClinicalTrials.gov Breast cancer trials 30 Unknown Publication search No Not applicable Funding source None
Walker et al. [36] JRSM Open. 2014 2011–2012 ClinicalTrials.gov, ISRCTN, national register based on first author nationality Trials from the Journal of the American Medical Association and BMJ 75 Unknown Publication search Yes Chan None Sample size, analytical plan
Wildt et al. [37] BMJ Open. 2011 1980–2011 ClinicalTrials.gov Trials on diseases of the digestive system 66 1 January 2009 Registry search No Not described None Sample size
You et al. [38] J Clin Oncol. 2012 2005–2009 ClinicalTrials.gov, ISRCTN Adult solid tumor oncology trials 134 August 2009 Publication search No Not applicable Funding source, journal impact factor, publication year, location of author None
  1. ISRCTN International Standard Randomised Controlled Trial Number registry, ICMJE International Committee of Medical Journal Editors, WHO World Health Organization