New players in the preventive treatment of migraine

Table 2 Comparison between CGRP monoclonal antibodies, transcutaneous supraorbital nerve stimulation and current available oral treatments in the prevention of episodic migraine

Drug	LY2951742 [33]	ALD403 [32]	TEV48125 [35]	AMG334 [34]	tSNS [42]	Valproate [37]	Topiramate [37]	Propranolol [37]	Amitriptyline [37]
NNT	4	4.7	3.2	5.9	3.8	4	3	4	4
NNH	20	20	∞	NA	∞	7-14	2-17	NA	NA
Relative risk for AE	1.07	1.09	1	NA	1	1.2	1.8	2.1	1.9
NNT for discontinuation due to AE	∞	∞	∞	NA	∞	NA	16	16	19

tSNS: transcutaneous supraorbital nerve stimulation; NNT: number needed to treat; NNH: number needed to harm; AE: adverse event; NA: non applicable; ∞: NNH, same percentage of patients experienced any adverse event in both placebo and drug treated patients; NNTs for discontinuation due to adverse events, no patient treated with the drug discontinued because of adverse event

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