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Table 2 Cross-sectional associations of established risk factors for mortality and high oxidative stress levels defined by derivatives of reactive oxygen metabolites (d-ROMs) levels or total thiol levels (TTL)

From: Evidence for the free radical/oxidative stress theory of ageing from the CHANCES consortium: a meta-analysis of individual participant data

Risk factors for mortality Odds of high oxidative stress by
  d-ROMsa TTLb
Increasing age
Male sex
Decreasing education (↓)c
Increasing BMI (↓)d
Former smoking
Current smoking
No alcohol consumption
High alcohol consumptione
No performance of vigorous physical activity
Increasing total cholesterol
Decreasing HDL cholesterol (↓)f
Increasing CRP
Renal impairmentg
History of hypertension
History of diabetes
History of MI
History of stroke
History of cancer
  1. ad-ROMs >400 Carr U
  2. bLowest quartile of TTL in the different cohorts, i.e. ESTHER <281.57 μmol/L; HAPIEE Poland cases and eligible controls <464 μmol/L; HAPIEE Czech Republic cases and eligible controls <371 μmol/L; HAPIEE Lithuania cases and eligible controls <283 μmol/L
  3. cNo association in age- and sex-adjusted model (Additional file 1: Table S4)
  4. dNo association in main model for all BMI categories with exception of the highest BMI category, which showed a statistically significantly increased odds for high oxidative stress (Additional file 1: Table S3)
  5. eDefinition of high alcohol consumption: women ≥20 and men ≥40 g ethanol per day
  6. fNo association in main model (Additional file 1: Table S3)
  7. gEstimated glomerular filtration rate <60 mL/min/1.73 m2
  8. BMI, Body mass index; CRP, C-reactive protein; HDL, High-density lipoprotein; MI, Myocardial infarction; d-ROMs, Derivatives of reactive oxygen metabolites; TTL, Total thiol levels