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Table 4 Joint risk assessment for cardiovascular disease mortality by derivatives of reactive oxygen metabolites (d-ROMs) levels and total thiol levels (TTL)

From: Evidence for the free radical/oxidative stress theory of ageing from the CHANCES consortium: a meta-analysis of individual participant data

High oxidative stress by Proportion of population ncases RR (95 % CI)c
d-ROMsa TTLb ESTHER HAPIEE controls ESTHER + HAPIEE ESTHER + HAPIEE
No No 59 % 49 % 227 Ref
No Yes 18 % 25 % 108 1.34 (0.91–1.97)
Yes No 16 % 18 % 155 1.72 (1.27–2.32)*
Yes Yes 7 % 9 % 70 2.47 (1.58–3.98)*
  1. *Statistically significant (P <0.05)
  2. ad-ROMs levels >400 Carr U
  3. bLowest quartile of TTL in the different cohorts, i.e. ESTHER <281.57 μmol/L; HAPIEE Poland cases and eligible controls <464 μmol/L; HAPIEE Czech Republic cases and eligible controls <371 μmol/L; HAPIEE Lithuania cases and eligible controls <283 μmol/L
  4. cMeta-analysis of HAPIEE Poland, Czech Republic, Lithuania and ESTHER study. Model controlled for age, sex, education, BMI, smoking status, alcohol consumption and vigorous physical activity
  5. CI, Confidence interval; ncases, Incident case numbers; RR, Risk ratio