TY - JOUR AU - Duru, Valentine AU - Khim, Nimol AU - Leang, Rithea AU - Kim, Saorin AU - Domergue, Anais AU - Kloeung, Nimol AU - Ke, Sopheakvatey AU - Chy, Sophy AU - Eam, Rotha AU - Khean, Chanra AU - Loch, Kaknika AU - Ken, Malen AU - Lek, Dysoley AU - Beghain, Johann AU - Ariey, Frédéric AU - Guerin, Philippe J. AU - Huy, Rekol AU - Mercereau-Puijalon, Odile AU - Witkowski, Benoit AU - Menard, Didier PY - 2015 DA - 2015/12/22 TI - Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations JO - BMC Medicine SP - 305 VL - 13 IS - 1 AB - The declining efficacy of dihydroartemisinin-piperaquine against Plasmodium falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests resistance to both artemisinin and piperaquine. Available in vitro piperaquine susceptibility assays do not correlate with treatment outcome. A novel assay using a pharmacologically relevant piperaquine dose/time exposure was designed and its relevance explored in retrospective and prospective studies. SN - 1741-7015 UR - https://doi.org/10.1186/s12916-015-0539-5 DO - 10.1186/s12916-015-0539-5 ID - Duru2015 ER -