Table 3 Logistic regression model analyses of chemotherapy response in the combined cohorta
Univariate analysis | Multivariable analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signatures | n | pCR rate | OR | Lower 95 % | Upper 95 % | P value | auROC | OR | Lower 95 % | Upper 95 % | P value | auROC |
Age, years (cont. variable) | – | – | 1.0 | 0.97 | 1.00 | 0.027 | 0.547 | 0.99 | 0.97 | 1.01 | 0.178 | 0.744 |
Tumor size | ||||||||||||
T0-T2 | 556 | 24 % | 1.0 | – | – | – | 0.519 | 1.0 | – | – | – | |
T3-T4 | 353 | 12 % | 0.8 | 0.55 | 1.02 | 0.071 | 0.6 | 0.50 | 0.84 | 0.001 | ||
ER IHC | ||||||||||||
Positive | 487 | 11 % | 1.0 | – | – | – | 0.679 | 1.0 | – | – | – | |
Negative | 415 | 37 % | 4.7 | 3.39 | 6.61 | <0.001 | 1.8 | 0.99 | 3.34 | 0.052 | ||
PR IHC | ||||||||||||
Positive | 393 | 12 % | 1.0 | – | – | – | 0.643 | 1.0 | – | – | – | |
Negative | 507 | 33 % | 3.8 | 2.64 | 5.36 | <0.001 | 1.1 | 0.65 | 1.89 | 0.716 | ||
HER2 STATUS | ||||||||||||
Negative | 799 | 22 % | 1.0 | – | – | – | 0.533 | 1.0 | – | – | – | |
Positive | 88 | 35 % | 2.1 | 1.30 | 3.30 | 0.002 | 1.3 | 0.64 | 2.51 | 0.492 | ||
PAM50 | ||||||||||||
Luminal A | 281 | 6 % | 1.0 | – | – | – | 0.719 | 1.0 | – | – | – | |
Luminal B | 168 | 16 % | 3.0 | 1.57 | 5.64 | 0.001 | 3.3 | 1.72 | 6.45 | <0.001 | ||
HER2-E | 93 | 37 % | 8.9 | 4.69 | 17.09 | <0.001 | 6.1 | 2.75 | 13.38 | <0.001 | ||
Basal-like | 296 | 38 % | 9.6 | 5.49 | 15.40 | <0.001 | 6.1 | 2.94 | 12.66 | <0.001 | ||
Normal-like | 72 | 29 % | 6.4 | 3.16 | 12.96 | <0.001 | – | – | – | – | ||
STUDY | ||||||||||||
HORAK | 253 | 27 % | 1.0 | – | – | – | 0.553 | 1.0 | – | – | – | |
ISPY | 54 | 31 % | 1.2 | 0.65 | 2.32 | 0.532 | 1.3 | 0.55 | 3.16 | 0.540 | ||
MDACC508 | 488 | 20 % | 0.7 | 0.48 | 0.97 | 0.032 | 0.9 | 0.58 | 1.33 | 0.526 | ||
MIYAKE | 115 | 23 % | 0.8 | 0.49 | 1.37 | 0.443 | 1.0 | 0.55 | 1.95 | 0.910 | ||