Toxicity | n (Univariable analysis) | n (Multivariable analysis) | BCSS | RFS | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Unadjusted | Adjusted | Unadjusted | Adjusted | |||||||
HR (95Â % CI) | P value | HR (95Â % CI) | P value | HR (95Â % CI) | P value | HR (95Â % CI) | P value | |||
Neutropeniaa | 5886 | 5211 | 0.85 (0.74–0.98) | 0.02 | 0.87 (0.75–1.01) | 0.06 | 0.85 (0.76–0.95) | 0.004 | 0.86 (0.76–0.97) | 0.02 |
Nausea | 6248 | 5468 | 1.11 (0.93–1.33) | 0.25 | 1.09 (0.90–1.33) | 0.37 | 1.07 (0.91–1.25) | 0.42 | 1.06 (0.90–1.26) | 0.47 |
Vomiting | 6248 | 5468 | 0.98 (0.80–1.19) | 0.80 | 1.03 (0.84–1.28) | 0.76 | 1.00 (0.85–1.18) | >0.99 | 1.05 (0.88–1.26) | 0.57 |
Stomatitis | 6248 | 5468 | 1.20 (0.89–1.63) | 0.24 | 1.25 (0.90–1.74) | 0.19 | 1.09 (0.83–1.43) | 0.54 | 1.12 (0.83–1.50) | 0.46 |
Constipation | 5886 | 5211 | 0.91 (0.80–1.04) | 0.17 | 0.95 (0.82–1.09) | 0.45 | 0.91 (0.82–1.01) | 0.09 | 0.94 (0.83–1.05) | 0.27 |
Diarrhoea | 6248 | 5468 | 0.93 (0.68–1.26) | 0.64 | 0.98 (0.70–1.38) | 0.93 | 1.08 (0.85–1.37) | 0.54 | 1.19 (0.92–1.55) | 0.18 |
Infection | 6248 | 5468 | 1.09 (0.97–1.22) | 0.14 | 1.01 (0.90–1.15) | 0.82 | 1.06 (0.96–1.16) | 0.26 | 1.01 (0.91–1.12) | 0.88 |
Fatigue | 6248 | 5468 | 1.24 (1.07–1.43) | 0.004 | 1.17 (0.99–1.37) | 0.06 | 1.17 (1.03–1.32) | 0.01 | 1.13 (0.99–1.30) | 0.08 |
Anaemia | 3943 | 3582 | 1.18 (0.97–1.42) | 0.09 | 1.14 (0.93–1.39) | 0.21 | 1.11 (0.95–1.30) | 0.20 | 1.08 (0.91–1.28) | 0.36 |
Combined haematological | 3943 | 3582 | 0.89 (0.77–1.03) | 0.11 | 0.88 (0.76–1.03) | 0.12 | 0.88 (0.78–0.99) | 0.03 | 0.88 (0.78–1.00) | 0.06 |
Neurotoxicity | 3943 | 3582 | 0.96 (0.82–1.13) | 0.64 | 0.99 (0.84–1.17) | 0.90 | 0.98 (0.86–1.12) | 0.78 | 0.99 (0.87–1.14) | 0.94 |
Myalgia | 3943 | 3582 | 0.95 (0.82–1.09) | 0.43 | 1.03 (0.89–1.20) | 0.69 | 0.95 (0.84–1.06) | 0.34 | 1.02 (0.91–1.16) | 0.70 |
Fever | 3943 | 3582 | 0.98 (0.67–1.44) | 0.91 | 0.84 (0.57–1.26) | 0.41 | 1.08 (0.80–1.46) | 0.63 | 0.98 (0.71–1.34) | 0.88 |