Skip to main content

Advertisement

Table 1 Characteristics of development and validation cohorts for those aged 60–79 years (before multiple imputation)

From: Predicting dementia risk in primary care: development and validation of the Dementia Risk Score using routinely collected data

  Development cohort n = 800,013 Median follow-up 5 years (IQR, 3.15–5 years) Dementia events n = 6,017 Validation cohort n = 226,140 Median follow-up 5 years (IQR, 3.27–5 years) Dementia events n = 1,699
  Obs Mean SD Obs Mean SD
Baseline age, years 800,013 65.6 6.08 226,140 65.6 6.11
Baseline total cholesterol, mmol/L 242,045 5.21 1.13 64,832 5.25 1.13
Baseline HDL cholesterol, mmol/L 167,937 1.42 0.41 45,682 1.42 0.42
Baseline weight, kg 226,671 79.2 16.9 59,594 79.1 16.8
Baseline systolic blood pressure, mmHg 452,306 142.4 17.0 125,744 142.7 17.1
Height, m 553,195 1.67 0.10 159,136 1.67 0.10
Baseline BMI, kg/m2 193,524 28.5 5.44 51,590 28.4 5.36
Baseline lipid ratio 166,420 3.88 1.17 45,352 3.91 1.17
  Obs Freq % Obs Freq %
Sex 800,013    226,140   
Men   386,039 48.3   109,108 48.3
Women   413,974 51.8   117,032 51.8
Local area deprivation score (quintiles) 800,013    226,140   
1 (=least deprived)   218,198 27.3   71,040 31.4
2   194,637 24.3   57,763 25.5
3   166,956 20.9   42,278 18.7
4   134,103 16.8   33,945 15.0
5 (=most deprived)   86,119 10.8   21,114 9.3
Baseline smoking status 756,115    213,419   
Never   323,345 42.8   96,256 45.1
Past   286,763 37.9   78,608 36.8
Current   146,007 19.3   38,555 18.1
History of very heavy drinking/alcohol problem 800,013 22,308 2.8 226,140 6,011 2.7
History of diabetes 800,013 70,377 8.8 226,140 18,662 8.3
History of coronary heart disease 800,013 93,408 11.7 226,140 26,016 11.5
History of stroke or transient ischemic attack 800,013 38,976 4.9 226,140 10,930 4.8
History of atrial fibrillation 800,013 24,763 3.1 226,140 7,085 3.1
Depression or use of anti-depressants at baseline 800,013 83,464 10.4 226,140 23,583 10.4
Anxiety or use of anxiolytics at baseline 800,013 29,690 3.7 226,140 8,549 3.8
Use of anti-hypertensive drugs at baseline 800,013 274,657 34.3 226,140 75,359 33.3
Use of statins at baseline 800,013 151,275 18.9 226,140 39,738 17.6
Use of hypnotics at baseline 800,013 30,787 3.9 226,140 8,736 3.9
Use of NSAIDs (other than aspirin) at baseline 800,013 98,397 12.3 226,140 27,546 12.2
Use of aspirin at baseline 800,013 127,550 15.9 226,140 34,756 15.4