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Table 3 Characteristics of development and validation cohorts for those aged 80–95 years (before imputation)

From: Predicting dementia risk in primary care: development and validation of the Dementia Risk Score using routinely collected data

  Development cohort n = 130,382 Median follow-up 3.76 years (IQR, 1.71–5 years) Dementia events n = 7,104 Validation cohort n = 38,084 Median follow-up 3.92 years (IQR, 1.75–5 years) Dementia events n = 1,923
  Obs Mean SD Obs Mean SD
Baseline age, years 130,382 84.8 3.93 38,084 84.9 3.97
Baseline total cholesterol, mmol/L 26,841 4.99 1.19 6,785 5.08 1.21
Baseline HDL cholesterol, mmol/L 16,630 1.50 0.44 4,066 1.49 0.44
Baseline weight, kg 31,272 67.1 14.0 8,038 67.2 13.8
Baseline systolic blood pressure, mmHg 78,979 146.9 19.8 22,347 147.5 19.8
Height, m 62,622 1.62 0.10 17,616 1.62 0.10
Baseline BMI, kg/m2 24,091 25.7 4.65 6,213 25.7 4.53
Baseline lipid ratio 16,566 3.49 1.10 4,054 3.57 1.13
  Obs Freq % Obs Freq %
Sex 130,382    38,084   
Men   44,286 34.0   13,017 34.2
Women   86,096 66.0   25,067 65.8
Local area deprivation score (quintiles) 130,382    38,084   
1 (=least deprived)   26,643 20.4   10,048 26.4
2   30,143 23.1   9,307 24.4
3   28,970 22.2   7,830 20.6
4   26,758 20.5   6,644 17.5
5 (=most deprived)   17,868 13.7   4,255 11.2
Baseline smoking status 113,391    32,702   
Never   63,684 56.2   19,389 59.3
Past   39,778 35.1   10,697 32.7
Current   9,929 8.8   2,616 8.0
History of very heavy drinking/alcohol problem 130,382 921 0.7 38,084 250 0.7
History of diabetes 130,382 12,762 9.8 38,084 3,331 8.8
History of coronary heart disease 130,382 28,190 21.6 38,084 8,281 21.7
History of stroke or transient ischemic attack 130,382 20,221 15.5 38,084 5,824 15.3
History of atrial fibrillation 130,382 14,518 11.1 38,084 4,293 11.3
Depression or use of anti-depressants at baseline 130,382 17,201 13.2 38,084 4,886 12.8
Anxiety or use of anxiolytics at baseline 130,382 5,953 4.6 38,084 1,816 4.8
Use of anti-hypertensive drugs at baseline 130,382 58,323 44.7 38,084 16,396 43.1
Use of statins at baseline 130,382 16,546 12.7 38,084 4,111 10.8
Use of hypnotics at baseline 130,382 14,121 10.8 38,084 4,137 10.9
Use of NSAIDs (other than aspirin) at baseline 130,382 15,056 11.6 38,084 4,430 11.6
Use of aspirin at baseline 130,382 41,448 31.8 38,084 11,830 31.1