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Table 2 Hazard ratios (95 % CIs) of cancer across quartiles of lysoPC a C18:0 and PC ae C30:0 concentrations

From: Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study

  

Quartile 1

Quartile 2

Quartile 3

Quartile 4

ptrend (raw)

ptrend (corrected)

Measured in

LysoPC a C18:0

       

100 %

Breast cancer

Mediana

13.52

17.34

20.36

23.23

   
 

n cases

137

96

84

45

   
  

Ref.

0.63 (0.41, 0.97)

0.65 (0.41, 1.02)

0.29 (0.18, 0.47)

0.00004

0.00421

 

Prostate cancer

Median

15.33

18.69

21.43

26.3

   
 

n cases

93

96

73

48

   
  

Ref.

1.31 (0.75, 2.28)

0.79 (0.45, 1.39)

0.57 (0.33, 0.98)

0.01388

1

 

Colorectal cancer

Median

14.37

17.71

21.21

24.13

   
 

n cases

47

47

46

23

   
  

Ref.

1.16 (0.67, 2.01)

1.06 (0.62, 1.82)

0.50 (0.28, 0.90)

0.00196

0.2348

 

Overall cancer

Median

14.37

17.93

20.85

24.63

   
 

n cases

280

228

211

116

   
  

Ref

0.83 (0.61, 1.12)

0.74 (0.55, 1.00)

0.37 (0.27, 0.51)

1.10 × 10−9

1.10 × 10−7

 

PC ae C30:0

       

95.6 %

Breast cancer

Median

0.33

0.40

0.47

0.60

   
 

n cases

69

74

92

113

   
  

Ref.

1.08 (0.67, 1.75)

1.45 (0.88, 2.37)

1.97 (1.20, 3.23)

0.00522

0.6260

 

Prostate cancer

Median

0.28

0.35

0.4

0.53

   
 

n cases

64

63

71

100

   
  

Ref.

0.89 (0.50, 1.58)

1.38 (0.78, 2.44)

1.89 (1.06, 3.36)

0.00194

0.2328

 

Colorectal cancer

Median

0.28

0.38

0.45

0.59

   
 

n cases

36

36

46

39

   
  

Ref

1.00 (0.54, 1.83)

1.79 (1.01, 3.18)

1.84 (1.02, 3.34)

0.01069

1

 

Overall cancer

Median

0.30

0.37

0.44

0.58

   
 

n cases

168

174

208

253

   
  

Ref

1.03 (0.73, 1.45)

1.41 (1.01, 1.96)

1.85 (1.31, 2.60)

0.00026

0.03137

 
  1. Results from Cox proportional hazards regression analyses on pre-diagnostic metabolite concentrations and cancer risk over time. All multivariable Cox models were adjusted for age, smoking (never, former, current), lifetime alcohol intake (g/d), current aspirin use (yes/no), physical activity (Cambridge index), waist circumference (cm), BMI (continuous), height (cm), and education level (primary school, secondary school, university degree). Analyses on breast cancer risk were additionally adjusted for menopausal status, current HRT use (yes/no), current oral contraceptive use (yes/no), and at least one full term pregnancy (yes/no). Analyses on colorectal cancer risk were additionally adjusted for sex, fiber intake (g/d), and processed meat intake (g/d). aMedian metabolite concentrations in μmol/L