Heterogeneous dynamics, robustness/fragility trade-offs, and the eradication of the macroparasitic disease, lymphatic filariasis

Table 1 Description of baseline survey data. The study sites are given with the baseline sample size and microfilariae (mf) prevalence (%), blood volumes collected during the survey to test for mf positivity, annual biting rate (ABR) of vector mosquitoes, dominant vector species and drug regimen used for simulating the chemotherapeutic interventions by mass drug administration (MDA) without/with vector control (VC)

Study villages	Sample size	Blood volume (μl)	^aMf (%)	^bBaseline ABR	Mosquito species (genus)	^cDrug regimen	^dDrug efficacies (ω, ε, P)	Source
Peneng	63	1,000	66.67	8,194	An	DEC + ALB	(55, 95, 6)	[8, 11, 78, 79]
Albulum	50	1,000	80	42,328	An	DEC + ALB	(55, 95, 6)	[8, 11, 78, 79]
Yauatong	131	1,000	92.37	37,052	An	DEC + ALB	(55, 95, 6)	[8, 11, 78, 79]
Nanaha	211	1,000	54.98	11,611	An	DEC + ALB	(55, 95, 6)	[8, 11, 78, 79]
Ngahmbule	346	1,000	51.16	4,346	An	DEC + ALB	(55, 95, 6)	[8, 11, 78, 79]
Masaika	848	100	28.61	6,184	An	IVM + ALB	(35, 99, 9)	[80]
Tawalani	367	100	35.72	12,850	An	IVM + ALB	(35, 99, 9)	[16]
Jaribuni	1,007	100	25.35	15,677	An	IVM + ALB	(35, 99, 9)	[81, 82]
Tingrela	699	20	63.89	4,156	An	IVM + ALB	(35, 99, 9)	[83]
Chiconi	245	20	58.90	10,586	An	IVM + ALB	(35, 99, 9)	[84]
Kingwede	825	100	3.07	1,548	Cx	IVM + ALB	(35, 99, 9)	[80]
Mao	546	100	27.8	25,439	Cx	IVM + ALB	(35, 99, 9)	[16]
Mambrui	787	100	24.99	4,964	Cx	IVM + ALB	(35, 99, 9)	[81, 82]
Pondicherry	1,549	20	34.74	88,500	Cx	DEC + ALB	(55, 95, 6)	[85]
Calcutta	861	20	26.72	115,942	Cx	DEC + ALB	(55, 95, 6)	[86, 87]
Vettavallam	7,976	20	22.83	100,375	Cx	DEC + ALB	(55, 95, 6)	[88]
Pakistan	1,443	20	31.49	1,607	Cx	DEC + ALB	(55, 95, 6)	[89, 90]
Jakarta	922	20	12.27	223,000	Cx	DEC + ALB	(55, 95, 6)	[91]

^aAll mf prevalence values were standardized to reflect sampling of 1 ml blood volumes using a transformation factor of 1.95 and 1.15, respectively, for values originally estimated using 20 or 100 μl blood volumes [49]; ^bbaseline ABR can be used to get monthly biting rate (MBR = ABR/12); ^cthe combination drug regimens are recommended by the WHO [92, 93]; ^dthe drug efficacy values are taken from [36]. An, Anopheles mosquitoes; Cx, Culex mosquitoes; drug efficacies (ω, ε, P) (instantaneous kill rate (%) for adult worms, instantaneous kill rate (%) for microfilariae, drug efficacy period in months); mf (%), microfilariae prevalence in percentages calculated from the number of mf-positive samples out of the total individuals sampled (sample size) in a study site. ALB, albendazole; DEC, diethylcarbamazine citrate; IVM, ivermectin

ISSN: 1741-7015