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Table 3 Table of area under the receiver operating characteristic curve (AUCROC) and 95 % confidence intervals for various models. Baseline covariates fitted in the adjusted models include those found to be significant in Table 2: BMI, history of smoking, HIV status, gender, presence of cavitation and baseline DTP in MGIT

From: Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials

  Control Isoniazid Ethambutol Combined (adjusted for treatment)
  Unadjusted Adjusted for baseline covariates Unadjusted Adjusted for baseline covariates Unadjusted Adjusted for baseline covariates Unadjusted Adjusted for baseline covariates
No on-treatment predictors (reference) 0.50 0.67 (0.57, 0.76) 0.50 0.70 (0.64, 0.77) 0.50 0.67 (0.61, 0.74) 0.60 (0.57, 0.64) 0.70 (0.66, 0.74)
BA(0–56), daily rate of change in log10(TTP) to day 56 0.60 (0.52, 0.69) 0.73 (0.66, 0.81) 0.61 (0.55, 0.68) 0.72 (0.65, 0.79) 0.61 (0.55, 0.67) 0.70 (0.64, 0.76) 0.66 (0.62, 0.70) 0.73 (0.69, 0.76)
Time to culture negative status on LJ 0.61 (0.50, 0.72) 0.73 (0.63, 0.82) 0.67 (0.60, 0.74) 0.74 (0.67, 0.81) 0.63 (0.57, 0.69) 0.71 (0.65, 0.77) 0.70 (0.66, 0.74) 0.74 (0.70, 0.78)
Time to culture negative status in MGIT 0.59 (0.49, 0.70) 0.77 (0.69, 0.84) 0.62 (0.55, 0.69) 0.74 (0.67, 0.80) 0.64 (0.57, 0.70) 0.72 (0.66, 0.78) 0.67 (0.63, 0.70) 0.74 (0.70, 0.78)
Time to smear negative status 0.62 (0.51, 0.72) 0.72 (0.64, 0.79) 0.62 (0.56, 0.69) 0.73 (0.67, 0.79) 0.59 (0.53, 0.66) 0.68 (0.62, 0.74) 0.66 (0.62, 0.70) 0.72 (0.68, 0.76)
Week 6 culture on LJ 0.55 (0.47, 0.63) 0.68 (0.60, 0.75) 0.56 (0.50, 0.62) 0.70 (0.63, 0.77) 0.56 (0.51, 0.61) 0.68 (0.61, 0.74) 0.63 (0.59, 0.67) 0.71 (0.67, 0.75)
Week 8 culture on LJ 0.51 (0.45, 0.56) 0.66 (0.57, 0.74) 0.56 (0.51, 0.61) 0.71 (0.64, 0.77) 0.56 (0.52, 0.60) 0.69 (0.63, 0.75) 0.63 (0.59, 0.66) 0.71 (0.66, 0.75)
Week 12 culture on LJ 0.55 (0.50, 0.60) 0.71 (0.63, 0.80) 0.51 (0.49, 0.53) 0.69 (0.63, 0.76) 0.53 (0.50, 0.55) 0.69 (0.63, 0.75) 0.62 (0.59, 0.66) 0.71 (0.67, 0.75)
Week 6 culture in MGIT 0.49 (0.41, 0.57) 0.65 (0.55, 0.74) 0.51 (0.45, 0.57) 0.70 (0.63, 0.76) 0.54 (0.49, 0.60) 0.65 (0.59, 0.72) 0.61 (0.57, 0.64) 0.70 (0.66, 0.74)
Week 8 culture in MGIT 0.56 (0.48, 0.64) 0.70 (0.61, 0.79) 0.57 (0.51, 0.63) 0.71 (0.64, 0.78) 0.61 (0.55, 0.66) 0.70 (0.64, 0.76) 0.64 (0.60, 0.68) 0.72 (0.68, 0.76)
Week 12 culture in MGIT 0.58 (0.51, 0.65) 0.72 (0.64, 0.80) 0.54 (0.49, 0.58) 0.71 (0.64, 0.77) 0.55 (0.51, 0.59) 0.69 (0.63, 0.75) 0.63 (0.59, 0.67) 0.72 (0.68, 0.76)
Week 6 smear 0.49 (0.41, 0.57) 0.65 (0.56, 0.75) 0.53 (0.47, 0.59) 0.70 (0.63, 0.76) 0.57 (0.52, 0.63) 0.68 (0.62, 0.75) 0.62 (0.58, 0.66) 0.71 (0.67, 0.75)
Week 8 smear 0.53 (0.46, 0.61) 0.68 (0.59, 0.77) 0.55 (0.49, 0.61) 0.71 (0.64, 0.77) 0.57 (0.52, 0.62) 0.69 (0.63, 0.75) 0.63 (0.59, 0.67) 0.71 (0.67, 0.75)
Week 12 smear 0.54 (0.48, 0.61) 0.68 (0.60, 0.77) 0.55 (0.50, 0.60) 0.70 (0.64, 0.77) 0.58 (0.53, 0.62) 0.68 (0.62, 0.74) 0.63 (0.60, 0.67) 0.71 (0.67, 0.75)