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Table 5 Age-stratified analyses of the associations of HbA1c levels with mortality and cardiovascular outcomes in subjects without diabetes mellitus

From: HbA1c levels in non-diabetic older adults – No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies

Outcome/stratum

Very low HbA1c (<5.0 %) (<31 mmol/mol)

Low HbA1c (5.0 to <5.5 %) (31 to <37 mmol/mol)

Intermediate HbA1c (5.5 to <6.0 %) (37 to <42 mmol/mol)

Increased HbA1c (6.0 to <6.5 %) (42 to <48 mmol/mol)

 

ntotal

ncases

IRa

HR (95 % CI)b

ntotal

ncases

IRa

HR

ntotal

ncases

IRa

HR (95 % CI)b

ntotal

ncases

IRa

HR (95 % CI)b

All-cause mortality

 50–64 years

1,688

205

10.0

0.95 (0.81; 1.12)

6,563

769

9.8

Ref

6,336

761

10.1

0.91 (0.82; 1.01)

1,514

272

15.8

1.18 (1.02; 1.37)

 ≥65 years

632

314

53.3

1.13 (1.01; 1.27)

3,779

1,556

42.6

Ref

4,767

1,978

43.3

1.06 (0.99; 1.13)

1,413

723

50.4

1.14 (1.04; 1.26)

Cardiovascular mortality

 50–64 years

1,218

61

3.7

0.99 (0.74; 1.33)

4,824

210

3.2

Ref

4,915

220

3.4

0.93 (0.76; 1.13)

1,194

78

5.3

1.14 (0.87; 1.50)

 ≥65 years

548

155

28.4

1.33 (0.86; 2.04)c

2,574

589

20.9

Ref

3,343

753

21.2

1.07 (0.82; 1.39)c d

1,035

249

24.2

1.18 (1.01; 1.38)

Cardiovascular events

 50–64 years

1,276

77

5.1

0.76 (0.60; 0.97)

5,626

456

8.1

Ref

5,470

507

9.6

1.09 (0.96; 1.25)

1,165

114

10.6

1.18 (0.95; 1.47)

 ≥65 years

409

82

22.4

1.15 (0.90; 1.46)

2,491

488

22.8

Ref

3,207

598

23.0

0.99 (0.88; 1.12)

846

171

26.7

1.19 (0.98; 1.45)

  1. Bold indicates statistically significant difference (p <0.05). aIR, incidence rate per 1,000 person-years. The IR is the weighted mean of the IRs of the individual studies (weighted by sample size); badjusted for age, sex, race/ethnicity, BMI, education, smoking, physical activity, alcohol consumption, total cholesterol, HDL cholesterol, CRP, hemoglobin, serum creatinine, albuminuria, hypertension and history of CVD; crandom effects model result reported due to statistical significant heterogeneity. CI, confidence interval; HbA1c, glycated hemoglobin; HR, hazard ratio; IR, incidence rate; n, sample size