Fig. 1
From: Policing of gut microbiota by the adaptive immune system
Interplay between IgA and the microbiota in the intestine. Schematic representation of IgA generation in the intestine, and how IgA population and intestinal microbiota regulate each other. Symbol 1: intestinal antigen sampling, mainly through M-cells process, is the first step in IgA plasma cells generation and IgA synthesis. IgA population and diversity will depend on antigenic peptides presented to the immune system by antigen-presenting cell. Symbol 2: after interaction with its receptor, IgA dimers are translocated to the lumen where they will provide mucosal immune protection. In addition, such secreted IgA can subsequently regulate microbiota composition, diversity, and gene expression. SED: sub-epithelial dome; DC: dendritic cell