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Table 1 First-line drug related SNPs identified in association and convergent evolution analysis

From: Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance

Drug Gene SNP mutations (% in resistant isolates)
Rifampicin rpoB T400A (3.8), D435V (9.4), H445D/Y (11.3),
   H445R (5.7), S450W/L (60.4), I491V/F (3.8)
Isoniazid katG S315N (69.2)
Isoniazid Rv1482c-fabG1 (inhA-promoter) C-15 T (24.6)
Streptomycin rpsL K43R (24.4)
Ethambutol embB C12T (5.9), M306I (14.7*), M306V (17.7*), D354A (11.8), G406S/C (11.8), G406D/A (11.8**), Q497P/R (17.7***), D1024N (8.8)
Ethambutol cadI C-39 T (8.8)
  1. The genes were identified using aggregated mutation mixed models. The SNPs were identified using the phyC method and those also found using the GWAS mixed model approach are highlighted in bold
  2. SNP single nucleotide polymorphism, GWAS genome-wide association study
  3. *observed in “sensitive” strains at frequency 3.2 %; **4.3 %; ***1.1 %; all P < 1 × 10-5 from association analysis