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Table 2 Second-line drug related mutations in candidate genes

From: Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance

Drug No. resistant Locus (codon [no. isolates])
Para-aminosalisylic acid 6 folC (E40G[1], I43G[1], D135G[1]);
thyA ( Y94C[1], Q97R[1], V135F[1]);
thyX promoter (G16A [2], T43G [1]).
Ethionamide 7 ethA (R469P[1]);
ethR-fabG1 promoter (C15T[6]);
inhA (S94[1])
Ofloxacin 3 gyrA (D94G [2]; N499D [1]).
Capreomycin 2 rrs (A1205G[1]); tlyA (G196E [1])
  1. Previously unreported in bold