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Table 3 Performance of drug-susceptibility testing with risk stratification for detection of drug-resistant tuberculosis (DR-TB)

From: Rationing tests for drug-resistant tuberculosis – who are we prepared to miss?

  N Percentage of subjects tested if only this subgroup was selected for drug-susceptibility testing (95 % CI) DR-TB cases identified from subgroup (n) Percentage of DR-TB cases identified (95 % CI) DR-TB cases missed (n) Percentage of DR-TB cases missed (95 % CI) Numbers needed to test to identify one DR-TB case
All patients 1,545 100.0 32 100.0 0 0.0 48
Patient subgroups       
≥1 MDR-TB risk factora 553 35.8 (33.4–38.2) 15 46.9 (29.6–64.2) 17 53.1 (35.8–70.4) 37
≥1 MDR-TB risk factor or smear positive sputumb 604 39.1 (36.7–41.5) 21 65.6 (49.2–82.1) 11 34.4 (17.9–50.8) 29
Sputum smear positive 82 5.3 (4.2–6.4) 14 43.8 (26.6–60.9) 18 56.3 (39.1–73.4) 6
Previous TB 309 20.0 (18.0–22.0) 11 34.4 (17.9–50.8) 21 65.6 (49.2–97.0) 28
Known contact with MDR-TB 161 10.4 (8.9–11.9) 5 15.6 (3.0–28.2) 27 84.4 (71.8–97.0) 32
Health worker 66 4.3 (3.3–5.3) 1 3.1 (0–9.2) 31 96.9 (90.8–100.0) 66
Current/ex prison worker or resident 38 2.5 (1.7–3.2) 1 3.1 (0–9.2) 31 96.9 (90.8–100.0) 38
HIV infection 18 1.2 (0.6–107) 0 0 32 100.0 n/a
  1. DR-TB, Drug-resistant tuberculosis; MDR-TB, Multidrug-resistant tuberculosis; CI, Confidence interval