Study | Sample | Data access | Country | Classes | Number | Case definition | Independent test setc | Validation setd | Evaluation of accuracye | Signature size | Metabolite biomarkers identified | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV status | Prior TB treatmenta | TB location | Microbiologically provenb | TST | IGRA | |||||||||||
Zhou et al., 2015 [109] | Plasma | N | China | TB | ? | P | Y | N | N | N | N/Af | Y | ||||
HC | ? | – | – | |||||||||||||
OD | 110 | – | – | |||||||||||||
Lau et al., 2015 [80] | Plasma | Y | Hong Kong | TB | 37 | – | P | Y | N | N | Y | 2 | Y | |||
HC | 30 | |||||||||||||||
OD | 30 | |||||||||||||||
Feng et al., 2015 [110] | Serum | N | China | TB | 120 | P | U | N | N | Y | 4 | Y | ||||
HC | 105 | |||||||||||||||
OD | 146 | |||||||||||||||
Mason et al., 2015 [111] | CSF | N | South Africa, The Netherlands | EP-TB | 17 | – | EP, P | Y | N | N | N | N/Af | Y | |||
OD | 49 | – | ||||||||||||||
Das et al., 2015 [82] | Urine | N | India | TB | 21 | – | – | P | Y | N | N | Y | 42 | Y | ||
OD | 21 | – | – | |||||||||||||
Frediani et al., 2014 [86] | Plasma | N | Georgia | TB | 17 | ≤7d | P | Y | N | N | N | N/Af | Y | |||
HC | 17 | |||||||||||||||
Mahapatra et al., 2014 [89] | Urine | N | Uganda, South Africa | TB | 87 | – | – | P | Y | N | N | Y | 6 | Y | ||
Treated | 59 | – | 1 m | |||||||||||||
Treated | 20 | – | 2 m | |||||||||||||
Treated | 54 | – | 6 m | |||||||||||||
Zhou et al., 2013 [112] | Serum | N | China | TB | 38 | P, EP | Y | N | N | N | N/Af | Y | ||||
HC | 39 | – | – | |||||||||||||
Che et al., 2013 [113] | Serum | N | China | TB | 136 | – | – | P, EP | U | Y | N | Y | 1 | Y | ||
Treated | 6 | – | 2 m | |||||||||||||
HC | 130 | – | ||||||||||||||
Du Preez and Loots 2013 [87] | Sputum | N | South Africa | TB | 34 | P | Y | N | N | N | N/Af | Y | ||||
OD | 61 | |||||||||||||||
Weiner et al., 2012 [81] | Serum | N | South Africa | TB | 44 | – | – | P | Y | N | N | Y | 20 | Y | ||
LTBI | 46 | – | + | |||||||||||||
HC | 46 | – | – | |||||||||||||
Kolk et al., 2012 [85] | Breath | N | South Africa | TB | 71 | + | P | Y | Y | N | Y | 7 | Y | |||
OD | 100 | |||||||||||||||
Banday et al., 2011 [84] | Urine | N | India | TB | 117 | – | P | Y | Y | N | Y | 5 | Y | |||
Treated | 20 | ≤7 m | ||||||||||||||
LTBI | 19 | + | ||||||||||||||
HC | 37 | – | ||||||||||||||
OD | 12 | |||||||||||||||
Phillips et al., 2010 [114] | Breath | N | US, Philippines, UK | TB g | 226 | – | P | U | N | N | Y | 10 | Y | |||
Phillips et al., 2007 [83] | Breath | N | US | TB | 23 | P | Y | +/– | N | N | Y | 130 | Y | |||
LTBI | 19 | + | ||||||||||||||
OD | 59 | +/– | +/– |